Norepinephrine transporter

SLC6A2
Identifiers
Aliases	SLC6A2, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter
External IDs	OMIM: 163970 MGI: 1270850 HomoloGene: 816 GeneCards: SLC6A2
Targeted by Drug
amitriptyline, amoxapine, atomoxetine, bupropion, citalopram, clomipramine, desipramine, desvenlafaxine, dextroamphetamine, duloxetine, imipramine, levomilnacipran, lofepramine, maprotiline, mazindol, methylphenidate, nefazodone, nisoxetine, nomifensine, nortriptyline, phenelzine, protriptyline, quetiapine, esreboxetine, sibutramine, tapentadol, trimipramine, venlafaxine, zotepine
Gene ontology Molecular function • dopamine:sodium symporter activity • neurotransmitter:sodium symporter activity • norepinephrine:sodium symporter activity • monoamine transmembrane transporter activity • protein binding • symporter activity • metal ion binding • beta-tubulin binding • alpha-tubulin binding • norepinephrine transmembrane transporter activity Cellular component • integral component of membrane • plasma membrane • membrane • membrane raft • neuron projection • cell surface • integral component of plasma membrane Biological process • dopamine uptake involved in synaptic transmission • neurotransmitter transport • response to pain • monoamine transport • transport • chemical synaptic transmission • norepinephrine transport • transmembrane transport • response to drug Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6530	20538
Ensembl	ENSG00000103546	ENSMUSG00000055368
UniProt	P23975	O55192
RefSeq (mRNA)	NM_001043 NM_001172501 NM_001172502 NM_001172504	NM_009209
RefSeq (protein)	NP_001034 NP_001165972 NP_001165973 NP_001165975	NP_033235.3 NP_033235
Location (UCSC)	Chr 16: 55.66 – 55.71 Mb	Chr 8: 92.96 – 93 Mb
PubMed search

6530

20538

ENSG00000103546

ENSMUSG00000055368

P23975

O55192

NM_001043
NM_001172501
NM_001172502
NM_001172504

NM_009209

NP_001034
NP_001165972
NP_001165973
NP_001165975

NP_033235.3
NP_033235

The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.

NET is a monoamine transporter and is responsible for the sodium-chloride (Na⁺/Cl⁻)-dependent reuptake of extracellular norepinephrine (NE), which is also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, are the targets of many antidepressants and recreational drugs. In addition, an overabundance of NET is associated with ADHD. There is evidence that single-nucleotide polymorphisms in the NET gene (SLC6A2) may be an underlying factor in some of these disorders.

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Wikipedia