Dopamine receptor D2

DRD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AER
Identifiers
Aliases	DRD2, D2DR, D2R, dopamine receptor D2
External IDs	OMIM: 126450 MGI: 94924 HomoloGene: 22561 GeneCards: DRD2
Targeted by Drug
benzquinamide, LP-12, LP-211, LP-44, ropinirole, rotigotine, vilazodone, 7-hydroxy-2-(di-N-propylamino)tetralin, bromocriptine, dopamine, pergolide, pramipexole, quinelorane, quinpirole, sumanirole, apomorphine, aripiprazole, brexpiprazole, cabergoline, lisuride, piribedil, roxindole, terguride, amisulpride, blonanserin, (+)-butaclamol, chlorpromazine, clozapine, domperidone, eticlopride, (Z)-flupentixol, fluphenazine, haloperidol, L-741,626, loxapine, mesoridazine, nafadotride, olanzapine, perospirone, perphenazine, pimozide, pipotiazine, prochlorperazine, promazine, quetiapine, raclopride, risperidone, sertindole, sulpiride, levosulpiride, trifluoperazine, ziprasidone, zotepine
Gene ontology Molecular function • protein homodimerization activity • drug binding • protein heterodimerization activity • receptor binding • potassium channel regulator activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • identical protein binding • dopamine neurotransmitter receptor activity • ionotropic glutamate receptor binding • G-protein coupled receptor activity • protein binding • signal transducer activity • adrenergic receptor activity • dopamine binding Cellular component • cytoplasmic vesicle • sperm flagellum • endocytic vesicle • acrosomal vesicle • dendritic spine • synaptic vesicle membrane • perikaryon • plasma membrane • dendrite • ciliary membrane • axon terminus • integral component of membrane • postsynaptic density • membrane • lateral plasma membrane • axon • integral component of plasma membrane • intracellular • non-motile cilium Biological process • negative regulation of cell proliferation • temperature homeostasis • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenohypophysis development • circadian regulation of gene expression • response to toxic substance • regulation of dopamine secretion • response to cocaine • response to amphetamine • sensory perception of smell • locomotory behavior • positive regulation of urine volume • response to ethanol • axonogenesis • positive regulation of glial cell-derived neurotrophic factor secretion • response to inactivity • phospholipase C-activating dopamine receptor signaling pathway • modulation of synaptic transmission • grooming behavior • negative regulation of protein kinase B signaling • associative learning • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • regulation of dopamine uptake involved in synaptic transmission • regulation of synaptic transmission, GABAergic • positive regulation of dopamine uptake involved in synaptic transmission • signal transduction • Wnt signaling pathway • adult walking behavior • branching morphogenesis of a nerve • negative regulation of cytosolic calcium ion concentration • negative regulation of innate immune response • regulation of phosphoprotein phosphatase activity • regulation of cAMP metabolic process • acid secretion • feeding behavior • positive regulation of G-protein coupled receptor protein signaling pathway • response to axon injury • striatum development • synaptic transmission, dopaminergic • neurological system process involved in regulation of systemic arterial blood pressure • peristalsis • regulation of long-term neuronal synaptic plasticity • activation of protein kinase activity • positive regulation of growth hormone secretion • regulation of sodium ion transport • forebrain development • response to light stimulus • orbitofrontal cortex development • prepulse inhibition • response to morphine • response to iron ion • positive regulation of ERK1 and ERK2 cascade • long-term memory • positive regulation of renal sodium excretion • negative regulation of insulin secretion • neuron-neuron synaptic transmission • phosphatidylinositol metabolic process • intracellular signal transduction • auditory behavior • behavioral response to ethanol • regulation of heart rate • adenylate cyclase-activating adrenergic receptor signaling pathway • positive regulation of cytokinesis • regulation of potassium ion transport • pigmentation • cellular calcium ion homeostasis • dopamine metabolic process • response to nicotine • regulation of MAPK cascade • response to histamine • negative regulation of synaptic transmission, glutamatergic • response to hypoxia • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of protein secretion • synapse assembly • regulation of locomotion involved in locomotory behavior • dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • startle response • positive regulation of receptor internalization • protein localization • G-protein coupled receptor signaling pathway • arachidonic acid secretion • positive regulation of transcription from RNA polymerase II promoter • G-protein coupled receptor internalization • positive regulation of multicellular organism growth • positive regulation of long-term synaptic potentiation • negative regulation of dopamine secretion • adult behavior • cerebral cortex GABAergic interneuron migration • regulation of synapse structural plasticity • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • response to drug • visual learning • negative regulation of cell migration • behavioral response to cocaine • positive regulation of neuroblast proliferation • chemical synaptic transmission, postsynaptic • negative regulation of blood pressure • release of sequestered calcium ion into cytosol • negative regulation of adenylate cyclase activity • negative regulation of voltage-gated calcium channel activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1813	13489
Ensembl	ENSG00000149295	ENSMUSG00000032259
UniProt	P14416	P61168
RefSeq (mRNA)	NM_016574 NM_000795	NM_010077
RefSeq (protein)	NP_000786 NP_057658 NP_000786.1	NP_034207.2 NP_034207
Location (UCSC)	Chr 11: 113.41 – 113.48 Mb	Chr 9: 49.34 – 49.41 Mb
PubMed search

5AER

1813

13489

ENSG00000149295

ENSMUSG00000032259

P14416

P61168

NM_016574
NM_000795

NM_010077

NP_000786
NP_057658
NP_000786.1

NP_034207.2
NP_034207

Dopamine receptor D₂, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups (including those of Solomon Snyder and Philip Seeman) used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D₂ receptor. The dopamine D₂ receptor is the main receptor for all antipsychotic drugs.

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Wikipedia