Dopamine transporter

SLC6A3
Identifiers
Aliases	SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter
External IDs	OMIM: 126455 MGI: 94862 HomoloGene: 55547 GeneCards: SLC6A3
Targeted by Drug
atomoxetine, bupropion, clomipramine, desvenlafaxine, dextroamphetamine, dexmethylphenidate, gbr-12935, levomilnacipran, mazindol, methylphenidate, nomifensine, phenelzine, sibutramine, trimipramine, WIN35428
Gene ontology Molecular function • protein N-terminus binding • dopamine:sodium symporter activity • protein complex binding • metal ion binding • neurotransmitter:sodium symporter activity • protease binding • dopamine transmembrane transporter activity • dopamine binding • protein binding • drug binding • protein phosphatase 2A binding • receptor binding • symporter activity • monoamine transmembrane transporter activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • axon • flotillin complex • neuronal cell body • membrane raft • presynapse • neuron projection Biological process • response to cocaine • prepulse inhibition • response to organic cyclic compound • locomotory behavior • dopamine biosynthetic process • response to nicotine • aging • neurotransmitter biosynthetic process • monoamine transport • adenohypophysis development • regulation of dopamine metabolic process • response to iron ion • sensory perception of smell • dopamine uptake involved in synaptic transmission • dopamine catabolic process • dopamine transport • positive regulation of multicellular organism growth • transport • response to cAMP • lactation • response to ethanol • neurotransmitter transport • response to drug • dopamine uptake • transmembrane transport • ammonium transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6531	13162
Ensembl	n/a	ENSMUSG00000021609
UniProt	Q01959	Q61327
RefSeq (mRNA)	NM_001044	NM_010020
RefSeq (protein)	NP_001035	NP_034150.1 NP_034150
Location (UCSC)	Chr 5: 1.39 – 1.45 Mb	Chr 13: 73.54 – 73.58 Mb
PubMed search

6531

13162

n/a

ENSMUSG00000021609

Q01959

Q61327

NM_001044

NM_010020

NP_001035

NP_034150.1
NP_034150

The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synapse back into cytosol, from which other transporters sequester DA and NE into vesicles for storage and later release. Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses, although there may be an exception in the prefrontal cortex, where evidence points to a possibly larger role of the norepinephrine transporter.

DAT is implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder, bipolar disorder, clinical depression, and alcoholism. The gene that encodes the DAT protein is located on human chromosome 5, consists of 15 coding exons, and is roughly 64 kbp long. Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism, known as a VNTR, in the DAT gene (DAT1), which influences the amount of protein expressed.

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Wikipedia