GBR-12935

GBR-12935
Identifiers

IUPAC name 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine
CAS Number	76778-22-8^Y
PubChem CID	3456
IUPHAR/BPS	4639
ChemSpider	3338^N
ChEBI	CHEBI:64093^N
ChEMBL	CHEMBL26320^N
Chemical and physical data
Formula	C₂₈H₃₄N₂O
Molar mass	414.582 g/mol
3D model (Jmol)	Interactive image
SMILES C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4
InChI InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2^N Key:RAQPOZGWANIDQT-UHFFFAOYSA-N^N
^NY (what is this?)

GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its ³H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain.

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