Dopamine D1 receptor

DRD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OZ5
Identifiers
Aliases	DRD1, dopamine receptor D1, DADR, DRD1A
External IDs	MGI: 99578 HomoloGene: 30992 GeneCards: DRD1
Targeted by Drug
a-68930, apomorphine, cabergoline, dopamine, fenoldopam, pergolide, rotigotine, pathogen, bromocriptine, lisuride, SKF-38393, (+)-butaclamol, chlorpromazine, clozapine, ecopipam, (Z)-flupentixol, fluphenazine, haloperidol, ketanserin, mesoridazine, prochlorperazine, SCH-23390, spiperone, thioridazine
Gene ontology Molecular function • dopamine neurotransmitter receptor activity • dopamine binding • protein binding • dopamine neurotransmitter receptor activity, coupled via Gs • G-protein coupled receptor activity • signal transducer activity Cellular component • membrane • nucleus • endoplasmic reticulum • integral component of membrane • plasma membrane • endoplasmic reticulum membrane • integral component of plasma membrane • ciliary membrane • endomembrane system • non-motile cilium Biological process • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • muscle contraction • adenylate cyclase-activating G-protein coupled receptor signaling pathway • protein import into nucleus • positive regulation of potassium ion transport • response to amphetamine • learning • feeding behavior • long term synaptic depression • temperature homeostasis • striatum development • prepulse inhibition • response to cocaine • grooming behavior • behavioral response to cocaine • locomotory behavior • dentate gyrus development • transmission of nerve impulse • memory • positive regulation of synaptic transmission, glutamatergic • synapse assembly • habituation • adult walking behavior • peristalsis • cellular response to catecholamine stimulus • G-protein coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • regulation of dopamine uptake involved in synaptic transmission • associative learning • astrocyte development • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of release of sequestered calcium ion into cytosol • mating behavior • behavioral fear response • activation of adenylate cyclase activity • dopamine receptor signaling pathway • conditioned taste aversion • cerebral cortex GABAergic interneuron migration • glucose import • visual learning • sensitization • positive regulation of cell migration • operant conditioning • vasodilation • regulation of dopamine metabolic process • dopamine metabolic process • phospholipase C-activating dopamine receptor signaling pathway • maternal behavior • dopamine transport • hippocampus development • response to drug • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway • neuronal action potential • long-term synaptic potentiation • signal transduction • positive regulation of cAMP biosynthetic process • synaptic transmission, dopaminergic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1812	13488
Ensembl	ENSG00000184845	ENSMUSG00000021478
UniProt	P21728	Q61616
RefSeq (mRNA)	NM_000794	NM_001291801 NM_010076
RefSeq (protein)	NP_000785	NP_001278730.1 NP_034206.1 NP_001278730 NP_034206
Location (UCSC)	Chr 5: 175.44 – 175.44 Mb	Chr 13: 54.05 – 54.06 Mb
PubMed search

1OZ5

1812

13488

ENSG00000184845

ENSMUSG00000021478

P21728

Q61616

NM_000794

NM_001291801
NM_010076

NP_000785

NP_001278730.1
NP_034206.1
NP_001278730
NP_034206

Dopamine receptor D₁, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.

The D₁ subtype of the dopamine receptor is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor is Gs/a coupled and indirectly activates cyclic AMP-dependent protein kinase, stimulating the neuron. D₁ receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D₂-mediated events. Alternative transcription initiation sites result in two transcript variants of the gene.D1-D2 dopamine receptor heteromer formation is observed.

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