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D5 receptor

DRD5
Identifiers
Aliases DRD5, DBDR, DRD1B, DRD1L2, dopamine receptor D5
External IDs MGI: 94927 HomoloGene: 20216 GeneCards: DRD5
Targeted by Drug
a-68930, pathogen, beta-ergocriptine, bromocriptine, cabergoline, dopamine, pergolide, rotigotine, apomorphine, lisuride, SKF-38393, (+)-butaclamol, chlorpromazine, clozapine, ecopipam, (Z)-flupentixol, fluphenazine, haloperidol, ketanserin, SCH-23390, spiperone, thioridazine
RNA expression pattern
PBB GE DRD5 208486 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000798

NM_013503

RefSeq (protein)

NP_000789

NP_038531.1
NP_038531

Location (UCSC) Chr 4: 9.78 – 9.78 Mb Chr 5: 38.32 – 38.32 Mb
PubMed search

NM_000798

NM_013503

NP_000789

NP_038531.1
NP_038531

Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with the D1 receptor subtype.

D5 receptor is a subtype of the dopamine receptor that has a 10-fold higher affinity for dopamine than the D1 subtype. The D5 subtype is a G-protein coupled receptor, which promotes synthesis of cAMP by adenylyl cyclase via activation of s/olf family of G proteins. Both D5 and D1 subtypes activate adenylyl cyclase. D1 receptors were shown to stimulate monophasic dose-dependent accumulation of cAMP in response to dopamine, and the D5 receptors were able to stimulate biphasic accumulation of cAMP under the same conditions, suggesting that D5 receptors may use a different system of secondary messengers than D1 receptors.


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Wikipedia

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