D5 receptor

DRD5
Identifiers
Aliases	DRD5, DBDR, DRD1B, DRD1L2, dopamine receptor D5
External IDs	MGI: 94927 HomoloGene: 20216 GeneCards: DRD5
Targeted by Drug
a-68930, pathogen, beta-ergocriptine, bromocriptine, cabergoline, dopamine, pergolide, rotigotine, apomorphine, lisuride, SKF-38393, (+)-butaclamol, chlorpromazine, clozapine, ecopipam, (Z)-flupentixol, fluphenazine, haloperidol, ketanserin, SCH-23390, spiperone, thioridazine
Gene ontology Molecular function • G-protein coupled receptor activity • dopamine neurotransmitter receptor activity • signal transducer activity • dopamine binding • dopamine neurotransmitter receptor activity, coupled via Gs Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • brush border membrane • ciliary membrane • non-motile cilium Biological process • response to cocaine • cellular response to catecholamine stimulus • G-protein coupled receptor signaling pathway • regulation of female receptivity • sensitization • adenylate cyclase-activating dopamine receptor signaling pathway • positive regulation of adenylate cyclase activity • associative learning • adenylate cyclase-activating G-protein coupled receptor signaling pathway • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • transmission of nerve impulse • response to amphetamine • regulation of systemic arterial blood pressure by vasopressin • wound healing • cellular calcium ion homeostasis • mating behavior • learning • negative regulation of NAD(P)H oxidase activity • activation of adenylate cyclase activity • reactive oxygen species metabolic process • phospholipase C-activating dopamine receptor signaling pathway • long term synaptic depression • signal transduction • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway • chemical synaptic transmission • synaptic transmission, dopaminergic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1816	13492
Ensembl	ENSG00000169676	ENSMUSG00000039358
UniProt	P21918	Q8BLD9
RefSeq (mRNA)	NM_000798	NM_013503
RefSeq (protein)	NP_000789	NP_038531.1 NP_038531
Location (UCSC)	Chr 4: 9.78 – 9.78 Mb	Chr 5: 38.32 – 38.32 Mb
PubMed search

1816

13492

ENSG00000169676

ENSMUSG00000039358

P21918

Q8BLD9

NM_000798

NM_013503

NP_000789

NP_038531.1
NP_038531

Dopamine receptor D₅, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with the D₁ receptor subtype.

D₅ receptor is a subtype of the dopamine receptor that has a 10-fold higher affinity for dopamine than the D₁ subtype. The D₅ subtype is a G-protein coupled receptor, which promotes synthesis of cAMP by adenylyl cyclase via activation of Gα_s/olf family of G proteins. Both D₅ and D₁ subtypes activate adenylyl cyclase. D₁ receptors were shown to stimulate monophasic dose-dependent accumulation of cAMP in response to dopamine, and the D₅ receptors were able to stimulate biphasic accumulation of cAMP under the same conditions, suggesting that D₅ receptors may use a different system of secondary messengers than D₁ receptors.

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Wikipedia