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D1 receptor

DRD1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DRD1, dopamine receptor D1, DADR, DRD1A
External IDs MGI: 99578 HomoloGene: 30992 GeneCards: DRD1
Targeted by Drug
a-68930, apomorphine, cabergoline, dopamine, fenoldopam, pergolide, rotigotine, pathogen, bromocriptine, lisuride, SKF-38393, (+)-butaclamol, chlorpromazine, clozapine, ecopipam, (Z)-flupentixol, fluphenazine, haloperidol, ketanserin, mesoridazine, prochlorperazine, SCH-23390, spiperone, thioridazine
RNA expression pattern
PBB GE DRD1 214652 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000794

NM_001291801
NM_010076

RefSeq (protein)

NP_000785

NP_001278730.1
NP_034206.1
NP_001278730
NP_034206

Location (UCSC) Chr 5: 175.44 – 175.44 Mb Chr 13: 54.05 – 54.06 Mb
PubMed search

1OZ5

NM_000794

NM_001291801
NM_010076

NP_000785

NP_001278730.1
NP_034206.1
NP_001278730
NP_034206

Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor is Gs/a coupled and indirectly activates cyclic AMP-dependent protein kinase; stimulating the neuron. nuD1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternative transcription initiation sites result in two transcript variants of this gene.D1-D2 dopamine receptor heteromer formation is observed.


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Wikipedia

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