CCR1

CCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y5D
Identifiers
Aliases	CCR1, CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C motif chemokine receptor 1
External IDs	MGI: 104618 HomoloGene: 20344 GeneCards: CCR1
Gene ontology Molecular function • C-C chemokine binding • G-protein coupled receptor activity • chemokine (C-C motif) ligand 5 binding • signal transducer activity • chemokine (C-C motif) ligand 7 binding • protein binding • chemokine receptor activity • C-C chemokine receptor activity • phosphatidylinositol phospholipase C activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • external side of plasma membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of bone mineralization • cytokine-mediated signaling pathway • positive regulation of cell migration • positive regulation of cytosolic calcium ion concentration • chemokine-mediated signaling pathway • cell-cell signaling • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of monocyte chemotaxis • cellular calcium ion homeostasis • positive regulation of osteoclast differentiation • dendritic cell chemotaxis • negative regulation of gene expression • chemotaxis • cell surface receptor signaling pathway • cell adhesion • response to wounding • immune response • positive regulation of ERK1 and ERK2 cascade • inflammatory response • calcium ion transport • signal transduction • exocytosis • positive regulation of calcium ion transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1230	12768
Ensembl	ENSG00000163823	ENSMUSG00000025804
UniProt	P32246	P51675
RefSeq (mRNA)	NM_001295	NM_009912
RefSeq (protein)	NP_001286	NP_034042
Location (UCSC)	Chr 3: 46.2 – 46.21 Mb	Chr 9: 123.96 – 123.97 Mb
PubMed search

1Y5D

1230

12768

ENSG00000163823

ENSMUSG00000025804

P32246

P51675

NM_001295

NM_009912

NP_001286

NP_034042

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.

...
Wikipedia