CCL3

CCL3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Identifiers
Aliases	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
External IDs	OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3
Gene ontology Molecular function • protein kinase activity • cytokine activity • CCR5 chemokine receptor binding • chemokine activity • CCR1 chemokine receptor binding • kinase activity • phospholipase activator activity • calcium-dependent protein kinase C activity • protein binding • identical protein binding • chemoattractant activity Cellular component • cytoplasm • cytosol • intracellular • extracellular region • extracellular space Biological process • G-protein coupled receptor signaling pathway • signaling • negative regulation of bone mineralization • positive regulation of protein kinase B signaling • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • response to cholesterol • positive regulation of calcium-mediated signaling • behavior • regulation of sensory perception of pain • protein kinase B signaling • monocyte chemotaxis • negative regulation of osteoclast differentiation • astrocyte cell migration • positive regulation of cell migration • positive regulation of natural killer cell chemotaxis • chemokine-mediated signaling pathway • T cell chemotaxis • cell-cell signaling • cellular response to tumor necrosis factor • eosinophil chemotaxis • cellular response to organic cyclic compound • cellular calcium ion homeostasis • negative regulation of gene expression • neutrophil chemotaxis • cell activation • MAPK cascade • chemotaxis • negative regulation by host of viral transcription • positive regulation of GTPase activity • positive regulation of neuron apoptotic process • positive regulation of calcium ion import • macrophage chemotaxis • positive regulation of gene expression • cytoskeleton organization • positive regulation of interleukin-1 beta secretion • osteoblast differentiation • cellular response to interleukin-1 • immune response • positive regulation of ERK1 and ERK2 cascade • regulation of cell shape • positive regulation of tumor necrosis factor production • cellular response to interferon-gamma • lymphocyte chemotaxis • inflammatory response • granulocyte chemotaxis • response to toxic substance • eosinophil degranulation • lipopolysaccharide-mediated signaling pathway • calcium ion transport • calcium-mediated signaling • exocytosis • positive regulation of calcium ion transport • positive chemotaxis • positive regulation of inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6348	n/a
Ensembl	n/a	n/a
UniProt	P10147	n/a
RefSeq (mRNA)	NM_002983	n/a
RefSeq (protein)	NP_002974	n/a
Location (UCSC)	Chr 17: 36.09 – 36.09 Mb	n/a
PubMed search		n/a

1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR

6348

n/a

n/a

n/a

P10147

n/a

NM_002983

n/a

NP_002974

n/a

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5.

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