CCR2

CCR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KAD, 1KP1
Identifiers
Aliases	CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C motif chemokine receptor 2
External IDs	MGI: 106185 HomoloGene: 537 GeneCards: CCR2
Gene ontology Molecular function • CCR2 chemokine receptor binding • G-protein coupled receptor activity • protein homodimerization activity • signal transducer activity • chemokine receptor activity • C-C chemokine receptor activity • protein binding Cellular component • integral component of membrane • perikaryon • membrane • plasma membrane • integral component of plasma membrane • neuronal cell body • dendrite • perinuclear region of cytoplasm • cytoplasm • cytosol Biological process • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • JAK-STAT cascade • positive regulation of tumor necrosis factor biosynthetic process • positive regulation of immune complex clearance by monocytes and macrophages • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • negative regulation of eosinophil degranulation • cellular calcium ion homeostasis • positive regulation of interferon-gamma production • positive regulation of monocyte chemotaxis • positive regulation of CD8-positive, alpha-beta T cell extravasation • cellular homeostasis • dendritic cell chemotaxis • positive regulation of hematopoietic stem cell migration • T-helper 17 cell chemotaxis • chemotaxis • cellular defense response • blood vessel remodeling • positive regulation of monocyte extravasation • positive regulation of T cell activation • positive regulation of T-helper 1 type immune response • response to wounding • positive regulation of interleukin-2 production • positive regulation of T cell chemotaxis • immune response • positive regulation of alpha-beta T cell proliferation • regulation of vascular endothelial growth factor production • negative regulation of type 2 immune response • negative regulation of angiogenesis • inflammatory response • viral process • positive regulation of astrocyte chemotaxis • signal transduction • positive regulation of inflammatory response • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	729230	12772
Ensembl	ENSG00000121807	ENSMUSG00000049103
UniProt	P41597	P51683
RefSeq (mRNA)	NM_001123041 NM_001123396	NM_009915
RefSeq (protein)	NP_001116513 NP_001116868 NP_001116868.1	NP_034045
Location (UCSC)	Chr 3: 46.35 – 46.36 Mb	Chr 9: 124.1 – 124.11 Mb
PubMed search

1KAD, 1KP1

729230

12772

ENSG00000121807

ENSMUSG00000049103

P41597

P51683

NM_001123041
NM_001123396

NM_009915

NP_001116513
NP_001116868
NP_001116868.1

NP_034045

C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. CCR2 is a chemokine receptor.

This CCR2 gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

...
Wikipedia