Beta-2 adrenergic receptor

ADRB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QKX, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 5D5A, 5D5B, 5JQH
Identifiers
Aliases	ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, adrenoceptor beta 2
External IDs	OMIM: 109690 MGI: 87938 HomoloGene: 30948 GeneCards: ADRB2
Targeted by Drug
arformoterol, fenoterol, formoterol, indacaterol, mirabegron, olodaterol, metaproterenol, vilanterol, zinterol, epinephrine, Isoprenaline, salmeterol, dobutamine, ephedrine, pindolol, albuterol, terbutaline, alprenolol, atenolol, betaxolol, bupranolol, carazolol, carvedilol, cicloprolol, labetalol, levobetaxolol, levobunolol, metoprolol, nadolol, propafenone, propranolol, sotalol, sr-59230a free base
Gene ontology Molecular function • adenylate cyclase binding • adrenergic receptor activity • beta2-adrenergic receptor activity • enzyme binding • protein homodimerization activity • potassium channel regulator activity • protein binding • G-protein coupled receptor activity • signal transducer activity • norepinephrine binding • epinephrine binding Cellular component • endosome • membrane • nucleus • apical plasma membrane • lysosome • integral component of membrane • receptor complex • plasma membrane • early endosome • integral component of plasma membrane • endosome membrane • clathrin-coated vesicle membrane Biological process • positive regulation of autophagosome maturation • adenylate cyclase-activating G-protein coupled receptor signaling pathway • regulation of sodium ion transport • endosome to lysosome transport • receptor-mediated endocytosis • cell surface receptor signaling pathway • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • negative regulation of smooth muscle contraction • regulation of smooth muscle contraction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • bone resorption • adenylate cyclase-activating adrenergic receptor signaling pathway • heat generation • desensitization of G-protein coupled receptor protein signaling pathway by arrestin • positive regulation of MAPK cascade • regulation of vasodilation • G-protein coupled receptor signaling pathway • positive regulation of bone mineralization • activation of adenylate cyclase activity • brown fat cell differentiation • activation of transmembrane receptor protein tyrosine kinase activity • positive regulation of protein ubiquitination • negative regulation of multicellular organism growth • cell-cell signaling • diet induced thermogenesis • vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure • positive regulation of lipophagy • response to cold • positive regulation of transcription from RNA polymerase II promoter • signal transduction • protein deubiquitination • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	154	11555
Ensembl	ENSG00000169252	ENSMUSG00000045730
UniProt	P07550	P18762
RefSeq (mRNA)	NM_000024	NM_007420
RefSeq (protein)	NP_000015	NP_031446.2 NP_031446
Location (UCSC)	Chr 5: 148.83 – 148.83 Mb	Chr 18: 62.18 – 62.18 Mb
PubMed search

4QKX, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 5D5A, 5D5B, 5JQH

154

11555

ENSG00000169252

ENSMUSG00000045730

P07550

...
Wikipedia