Sotalol

Sotalol

Clinical data
Trade names	Betapace, other
AHFS/Drugs.com	Monograph
MedlinePlus	a693010
Pregnancy category	AU: C US: B (No risk in non-human studies)
Routes of administration	by mouth
Drug class	beta blocker
ATC code	C07AA07 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	90–100%
Metabolism	Not metabolized
Biological half-life	12 hours
Excretion	Kidney Mammary gland (In lactating females)
Identifiers
IUPAC name (RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
CAS Number	3930-20-9 Y
PubChem CID	5253
IUPHAR/BPS	7297
DrugBank	DB00489 Y
ChemSpider	5063 Y
UNII	A6D97U294I
KEGG	D08525 Y
ChEMBL	CHEMBL471 Y
Chemical and physical data
Formula	C12H20N2O3S
Molar mass	272.3624 g/mol
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
SMILES O=S(=O)(Nc1ccc(cc1)C(O)CNC(C)C)C
InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 Y Key:ZBMZVLHSJCTVON-UHFFFAOYSA-N Y

Sotalol is a medication used to treat heart arrhythmias. The U.S. Food and Drug Administration advises that sotalol only be used for serious arrhythmias, because its prolongation of the QT interval carries a small risk of life-threatening torsade de pointes.

It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties.

Sotalol was discovered in 1960, became widely used in the 1980s, and its function as an antiarrhythmic drug was discovered soon after.

According to the U.S. Food and Drug Administration (FDA), sotalol can be validly used to maintain normal heart rhythm in people with life-threatening ventricular arrhythmias, or very symptomatic atrial fibrillation or flutter. Due to the risk of serious side effects, the FDA states that sotalol should generally be reserved for people whose ventricular arrhythmias are life-threatening, or whose fibrillation/flutter cannot be resolved using the Valsalva maneuver or another simple method.

According to the FDA, sotalol should not be used in people with a waking heart rate lower than 50 beats per minute. It should not be used in people with sick sinus syndrome, long QT syndrome, cardiogenic shock, uncontrolled heart failure, bronchial asthma or a related bronchospastic condition, or people with serum potassium below 4 meq/L. It should only be used in people with a second and third degree AV block if a functioning pacemaker is present.