5-HT7

HTR7

Identifiers

HTR7, 5-HT7, 5-HT7 receptor, 5-hydroxytryptamine receptor 7

External IDs

MGI: 99841 HomoloGene: 20244 GeneCards: HTR7

Targeted by Drug

AS-19, LP-12, LP-44, 1-naphthylpiperazine, 5-carboxamidotryptamine, pathogen, 5-methoxytryptamine, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, EMDT, tryptamine, xanomeline, oleamide, bromolysergide, cyamemazine, cyproheptadine, dihydroergotamine, haloperidol, iloperidone, ketanserin, lurasidone, mesulergine, metergoline, metitepine, methysergide, mianserin, olanzapine, ritanserin, SB269970, spiperone, sumatriptan, vortioxetine, yohimbine, chlorpromazine, clozapine, fluperlapine, fluphenazine, perphenazine, risperidone, SB 258719, thioridazine, ziprasidone, zotepine

Gene ontology
Molecular function	• G-protein coupled receptor activity • signal transducer activity • neurotransmitter receptor activity • G-protein coupled serotonin receptor activity • serotonin binding
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • membrane
Biological process	• smooth muscle contraction • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G-protein coupled receptor signaling pathway • circadian rhythm • blood circulation • vasoconstriction • signal transduction • chemical synaptic transmission • adenylate cyclase-inhibiting serotonin receptor signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3363


15566

Ensembl


ENSG00000148680


ENSMUSG00000024798

UniProt


P34969


P32304

RefSeq (mRNA)


NM_019860 NM_000872 NM_019859


NM_008315 NM_001347442

RefSeq (protein)


NP_000863 NP_062873 NP_062874


NP_032341.2 NP_001334371 NP_032341

Location (UCSC)

Chr 10: 90.74 – 90.86 Mb

Chr 19: 35.96 – 36.06 Mb

PubMed search

NM_019860
NM_000872
NM_019859

NM_008315
NM_001347442

NP_000863
NP_062873
NP_062874

NP_032341.2
NP_001334371
NP_032341

The 5-HT₇ receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT₇ receptor is coupled to G_s (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT₇ receptor is encoded by the HTR7 gene, which in humans is transcribed into 3 different splice variants.

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