U.S. Route 50 in Indiana
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| Route information | ||||
| Maintained by INDOT | ||||
| Length: | 171.38 mi (275.81 km) | |||
| Existed: | 1926 – present | |||
| Major junctions | ||||
| West end: |
 US 50 towards Lawrenceville, IL
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 US 41 in Vincennes US 150 from Vincennes to Shoals I-69 in Washington US 231 in Loogootee I-65 in Seymour US 31 in Seymour US 421 in Versailles
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| East end: |
US 50 towards Cincinnati, OH
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| Highway system | ||||
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| Location: | North Vernon |
U.S. Route 50 (US 50) is a part of the United States Numbered Highway System that runs from West Sacramento, California, to Ocean City, Maryland. In the U.S. state of Indiana, it is part of the state road system. US 50 enters the state in Vincennes. The 171.38 miles (275.81 km) of US 50 that lie within Indiana serve as a major conduit. All of the highway is listed on the National Highway System. Various sections are rural two-lane highway, urbanized four-lane undivided highway and one-way streets. The easternmost community along the highway is Lawrenceburg at the Ohio state line. US 50 passes through urban areas, farmland and woodland.
US 50 enters Indiana over the Wabash River and a CSX railroad track as a four-lane, divided highway passing through rural farmland. The highway heads east, turning southeast, having a cloverleaf interchange with US 41 and US 150. The three routes head southeast; the concurrent ends when US 41 keeps heading south and US 50 and US 150 turn east. The two routes head east towards Washington, as a four-lane divided highway passing through rural farmland. In Wheatland the highway has an intersection with both SR 550 and SR 241. The road bypasses Washington around the south side of town, intersecting SR 57 and SR 257. On the east side of Washington the highway has an interchange with Interstate 69 (I–69). After the interchange with I–69, the highway narrows to a two-lane highway and heads east towards Loogootee.
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