U.S. Route 421 in Indiana
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_map.svg)
US 421 highlighted in red
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| Route information | ||||
| Maintained by INDOT | ||||
| Length: | 232 mi (373 km) | |||
| Existed: | 1951 – present | |||
| Major junctions | ||||
| South end: |
 US 421 near Madison
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 US 50 in Versailles I-74 Greensburg I-74 / I-465 in Indianapolis I-70 in Indianapolis I-69 in IndianapolisI-465 in Indianapolis US 24 in Monticello US 30 Wanatah   I-80 / I-90 / Indiana Toll Road near Otis I-94 near Michigan City
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| North end: |
 US 20 in Michigan City
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| Location | ||||
| Counties: | Jefferson, Ripley, Decatur, Shelby, Marion, Boone, Clinton, Carroll, White, Pulaski, Starke, LaPorte | |||
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U.S. Route 421 (US 421) enters Indiana from Kentucky, proceeding northwest to Indianapolis, joining Interstate 465, and then continuing northwest to Michigan City.
US 421 winds through the southern part of Indiana as it runs from Madison, in the southeastern part of the state, to Indianapolis (the capital). North of Greensburg, US 421 intersects and merges with I-74 west, through the Shelbyville area en route to Indianapolis. Originally, US 421 followed Southeastern Ave. into downtown Indianapolis, where it merged with US 40 (Washington St.) to West Street, then turned north, following West Street, Northwestern Avenue (later Martin Luther King Jr. Street), and Michigan Road up to the northwest side of the city. US 421 passed an Indianapolis landmark, the Pyramids. North of Indianapolis, US 421 continues to the north-northwest, providing a direct highway link between Indianapolis and Michigan City. US 421 ends at its junction with US 20 on the south side of Michigan City. Originally, the highway's end was a few miles north at the junction with US 12 near the shores of Lake Michigan.
US 421 enters Indiana from Kentucky over the Ohio River. After crossing the Ohio River US 421 has a short concurrency with State Road 56 (SR 56). After the concurrency with SR 56 ends US 421 becomes a four-lane highway. US 421 has an intersection with State Road 62 (SR 62). North of Madison US 421 becomes a two-lane highway, heading north then northeast. US 421 heads towards Versailles, passing through an intersection with State Road 250 (SR 250). In Versailles US 421 has a concurrency with State Road 129 that ends at U.S. Route 50 (US 50). US 421 heads west out of Versailles concurrenct with US 50. West of Varsailles US 421 heads northwest, towards Greensburg. US 421 passes through Osgood and Napoleon, passing through intersections with State Road 350 (SR 350) and State Road 48 (SR 48). US 421 enters Greensburg on the southeast side of town and heads to the northwest side of town. In Greensburg US 421 is concurrent with State Road 46 (SR 46) and intersects State Road 3 (SR 3). On the northwest side of Greensburg US 421 joins Interstate 74 (I-74). I-74/US 421 heads northwest towards Indianapolis, passing near Shelbyville. Near Shelbyville I-74/US 421 has interchanges with State Road 44 (SR 44) and State Road 9 (SR 9). I-74/US 421 enters Indianapolis on the southeast side of the city. US 421 heads north and west around Indianapolis, concurrenct with Interstate 465.
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