U.S. Route 50 in Ohio
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Route of US 50 in Ohio in red
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| Route information | ||||
| Maintained by ODOT | ||||
| Length: | 209 mi (336 km) | |||
| Major junctions | ||||
| West end: |
 US 50 at IN state line near Cleves
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 I-275 near Cincinnati   I-71 / I-75 / I-471 in CincinnatiI-275 near Milford US 68 in Fayetteville US 62 in Hillsboro  US 23 / US 35 in Chillicothe US 33 in Athens
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| East end: |
US 50 at WV state line at the Ohio River
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| Highway system | ||||
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U.S. Route 50 runs east–west across the southern part of the U.S. state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost part. Near Athens it becomes part of State Route 32, a four-lane divided highway known as Corridor D, and from Reedsville to the Ohio/West Virginia border it also overlaps State Route 7 before crossing into Parkersburg, West Virginia.
US 50 enters Ohio from Indiana at a traffic light with State Line Road. The route heads northeast as a four-lane undivided highway, passing through farmland and paralleling a railroad track. The highway passes under Interstate 275 before entering the extreme western suburbs of the greater Cincinnati area. The road has an at-grade crossing with a railroad track, before curving southeast. US 50 has a traffic signal at the intersection with SR 128. Southeast of SR 128, US 50 becomes a four-lane divided highway and cross over the Great Miami River. After the river the route enters Cleves and curves due south and passes through residential properties. In Cleves the highway has a traffic signal with SR 264, before leaving Cleves and entering North Bend. In North Bend the road continues to pass through woodland and residential properties, before passing the monument and tomb of President William Henry Harrison. The highway curves east-southeast and becomes a four-lane undivided highway, before leaving North Bend. The road parallels the Ohio River and passes through a mix of woodland, residential and industrial properties. The route begins to curve northeast and enters Cincinnati.
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