Parkersburg is a city in and the county seat of Wood County, West Virginia, United States. Located at the confluence of the Ohio and Little Kanawha rivers, it is the state's third-largest city and the largest city in the Parkersburg–Marietta–Vienna Metropolitan Statistical Area. The population was 31,492 at the 2010 census. Its peak of population was more than 44,000 in 1960. The city is about 14 miles south of Marietta, Ohio.

The Baltimore and Ohio Railroad reached Parkersburg in 1857, but lacked a crossing over the Ohio River until after the American Civil War. When the B&O completed the Parkersburg Bridge (CSX) 1868-1870 to Belpre, it was the longest railroad bridge in the world.

The Bureau of the Public Debt, an agency of the U.S. Treasury Department, was relocated from the Washington, D.C. metropolitan area in the late 20th century and headquartered in Parkersburg. In October 2012, it was merged with the Financial Management Service to form the Bureau of the Fiscal Service.

White settlers originally named the city Newport when they settled it in the late 18th century following the American Revolutionary War. This was part of a westward migration of settlers from parts of Virginia to the east, closer to the Atlantic Ocean. A town section was laid out on land granted to Alexander Parker for his Revolutionary War service. Virginia made grants of land to veterans for their war service. The title conflicts between Parker and the city planners of Newport were settled in 1809 in favor of his heirs. The town was renamed Parkersburg in 1810. It was chartered by the Virginia General Assembly in 1820. It was rechartered as a city in 1860.

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