U.S. Route 217 in South Carolina

U.S. Route 301
Route of US 301 in South Carolina highlighted in red
Route information
Auxiliary route of US 1
Maintained by SCDOT
Length:	190.3 mi (306.3 km)
Existed:	1970 – present
Major junctions
South end:	US 301 / SR 73 at the GA state line near Allendale
	US 278 in Allendale US 321 in Ulmer US 21 / US 601 in Orangeburg I-26 near Orangeburg US 176 near Elloree US 15 / I-95 near Summerton US 521 in Manning US 378 in Turbeville US 52 in Effingham US 76 / SC 327 near Mars Bluff
North end:	US 301 / US 501 / I‑95 at the NC state line near Hamer
Location
Counties:	Allendale, Bamberg, Orangeburg, Clarendon, Florence, Marion, Dillon
Highway system
United States Numbered Highway System List Special Divided Replaced South Carolina State Highway System Interstate U.S. State Scenic ← SC 300 SC 302 →

U.S. Route 301 (US 301) runs north–south from the Savannah River southwest of Allendale to Hamer approaching the South of the Border roadside attraction complex.

US 301 enters South Carolina over the Savannah River southwest of Allendale. Concurrencies include US 321 in and around Ulmer, US 601 between Bamberg and Orangeburg, then Interstate 95 (I-95) and US 15 in Santee, at exit 97 before all three move across Lake Marion. The US 15-301 concurrency leaves I-95 at exit 102, running in close proximity to I-95, but US 15 breaks away at Summerton. Other concurrencies include US 521 in Manning, US 52 between Effingham and just south of Florence, US 76 eastbound from east of Florence until Pee Dee, and finally joins US 501 in Latta, where they both approach the South of the Border roadside attraction complex at the interchange with I-95 on the north–South Carolina border.