South Carolina Highway 64 Business (Walterboro)
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 73.2 mi (117.8 km) | |||
| Existed: | 1926 – present | |||
| Major junctions | ||||
| West end: | Savannah River Site | |||
 US 278 in Barnwell US 321 in Olar US 301 near Olar US 601 in Ehrhardt US 21 in Bells Crossroads I-95 in Walterboro US 15 in Walterboro  US 17 Alt. in Walterboro
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| East end: |
US 17 in Jacksonboro
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| Location | ||||
| Counties: | Barnwell, Bamberg, Colleton | |||
| Highway system | ||||
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| Location: | Walterboro, South Carolina |
| Length: | 2.7 mi (4.3 km) |
| Existed: | 1985–present |
South Carolina Highway 64 (SC 64) is a primary state highway in the U.S. state of South Carolina. It serves the cities of Barnwell and Walterboro while also providing a direct route to Charleston, via U.S. Route 17.
Established around 1926 as a new primary routing from SC 28, near Ellenton, to SC 6/SC 301, near Ruffin. In 1928, SC 64 was extended east to US 17, in Walterboro, replacing part of SC 6. Around 1930, SC 64 was extended east again on new routing to US 78/SC 2, in Summerville. By 1932, SC 64 was extended east again at US 17, in Moncks Corner. In 1939, all sections of SC 64 were paved.
In 1950, SC 64 was extended in both directions: northeast with a concurrency with SC 28 to SC 781, in Beech Island; and east replacing SC 179 to Jamestown, then north in concurrency with SC 511, then east to end at US 521, west of Georgetown. This routing was the apex of SC 64, to a total of over 181 miles (291 km).
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