South Carolina Highway 6
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 116 mi (186 km) | |||
| Existed: | 1922 – present | |||
| Major junctions | ||||
| East end: |
 US 76 in Ballentine
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 I-95 in Santee I-26 near St. Matthews I-20 near Lexington
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| West end: |
 US 52 in Moncks Corner
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| Highway system | ||||
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South Carolina Highway 6 is a 115-mile (185 km) state highway that extends from Moncks Corner in Berkeley County to Ballentine in Richland County, near Irmo. It uniquely links all three of the major hydropower projects in South Carolina: Lake Murray, Lake Marion and Lake Moultrie.
The highway runs generally southeast from the central part of South Carolina to near the Atlantic Ocean and is listed as a hurricane evacuation route.
Beginning at a junction with U.S. Highway 52 in Moncks Corner, the route runs northwest along the shoreline of Lake Moultrie as West Main Street. It then turns right onto Ranger Drive. It turns left onto "Old Number Six Highway" where is later starts a concurrency with SC 45 as Eutaw Road. The concurrency runs and far from Lake Marion, and passes through Eutawville. There SC 45 departs to the west and SC 6 continues along the lake through Vance to Santee, where it intersects Interstate 95. It then adjoins the Santee State Park on its right. After a concurrency with SC 267 begins, it becomes Main Street through Elloree, South Carolina. The concurrency ends when SC 267 turns off to the right onto Lonestar Road. SC 6 then traverses St. Matthews as Bridge Street before having a brief concurrency with U.S. Highway 176. Route 26 turns left onto Caw Caw Highway and has an interchange with Interstate 26. The route turns right and head northwest in a concurrency with U.S. Route 21 and then separates from U.S. 21 onto Center Hill Road. It turns right on St. Matthews Road in a northwesterly direction, passing through Swansea as 2nd Street intersecting U.S. Route 321 in town and joining a concurrency with SC 302 as Edmund Hwy. The concurrency ends when SC 6 turns to the left onto S. Lake Drive where it heads northwest to Red Bank. In Red Bank, it intersects with Interstate 20.
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