Receptor activity-modifying protein

Receptor activity-modifying protein 1
Identifiers
Symbol	RAMP1
Entrez	10267
HUGO	9843
OMIM	605153
RefSeq	NM_005855
UniProt	O60894
Other data
Locus	Chr. 2 q36-37.1

Receptor activity-modifying protein 2
Identifiers
Symbol	RAMP2
Entrez	10266
HUGO	9844
OMIM	605154
RefSeq	NM_005854
UniProt	O60895
Other data
Locus	Chr. 17 q12-21.1

Receptor activity-modifying protein 3
Identifiers
Symbol	RAMP3
Entrez	10268
HUGO	9845
OMIM	605155
RefSeq	NM_005856
UniProt	O60896
Other data
Locus	Chr. 7 q13-p12

Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP). There are three distinct types of RAMPs, designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene.

Currently, the function of RAMPs is divided into classes of activities. When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) (below), RAMPs can change the selectivity of the receptor for a specific hormone. In the cases of the other receptors mentioned, however, there is no evidence that they can do this, but instead function to regulate trafficking of receptors from the ER / golgi to the membrane. These functions appear to be ones where there is redundancy, as neither RAMP1 nor RAMP3 knockout mice (KO) have grossly abnormal phenotypes. The likelihood is that the phenotype of RAMP2 KO mice is more connected with the abolition of most adrenomedullin (AM) signalling than effects on trafficking of other receptors, as those mice are almost identical to AM KO mice.

Association of RAMPs with either the CT or CALCRL proteins forms 6 different receptors from the calcitonin receptor family:

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