RAMP3

RAMP3
Identifiers
Aliases	RAMP3, entrez:10268, receptor activity modifying protein 3
External IDs	OMIM: 605155 MGI: 1860292 HomoloGene: 4276 GeneCards: RAMP3
Gene ontology Molecular function • coreceptor activity • protein transporter activity • protein binding • receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • receptor complex • integral component of plasma membrane • intracellular • cell surface • lysosome Biological process • G-protein coupled receptor signaling pathway • regulation of G-protein coupled receptor protein signaling pathway • cellular response to estradiol stimulus • receptor internalization • G-protein coupled receptor signaling pathway involved in heart process • positive regulation of establishment of protein localization to plasma membrane • transport • protein transport • protein localization to plasma membrane • intracellular protein transport • negative regulation of transcription, DNA-templated • calcium ion transport • positive regulation of receptor recycling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10268	56089
Ensembl	ENSG00000122679	ENSMUSG00000041046
UniProt	O60896	Q9WUP1
RefSeq (mRNA)	NM_005856	NM_019511
RefSeq (protein)	NP_005847	NP_062384
Location (UCSC)	Chr 7: 45.16 – 45.19 Mb	Chr 11: 6.66 – 6.68 Mb
PubMed search

10268

56089

ENSG00000122679

ENSMUSG00000041046

O60896

Q9WUP1

NM_005856

NM_019511

NP_005847

NP_062384

Receptor activity modifying protein 3, also known as RAMP3, is a human gene.

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.

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