Adrenomedullin

ADM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FLY, 2L7S, 4RWF
Identifiers
Aliases	ADM, Adm, AM, PAMP, adrenomedullin
External IDs	MGI: 108058 HomoloGene: 873 GeneCards: ADM
Gene ontology Molecular function • receptor binding • hormone activity • adrenomedullin receptor binding • protein binding Cellular component • extracellular region • cytoplasm • extracellular space Biological process • negative regulation of cell proliferation • response to hypoxia • positive regulation of cAMP biosynthetic process • neural tube closure • branching involved in labyrinthine layer morphogenesis • antibacterial humoral response • defense response to Gram-negative bacterium • receptor internalization • blood circulation • signal transduction • animal organ regeneration • cell-cell signaling • response to lipopolysaccharide • vascular smooth muscle cell development • defense response to Gram-positive bacterium • positive regulation of cytosolic calcium ion concentration • vasculogenesis • negative regulation of vasoconstriction • G-protein coupled receptor internalization • cAMP-mediated signaling • calcium ion homeostasis • response to starvation • heart development • regulation of the force of heart contraction • positive regulation of apoptotic process • response to yeast • response to cold • positive regulation of vasculogenesis • neuron projection regeneration • hormone secretion • antifungal humoral response • positive regulation of cell proliferation • response to glucocorticoid • developmental growth • aging • progesterone biosynthetic process • negative regulation of vascular permeability • androgen metabolic process • response to insulin • positive regulation of angiogenesis • response to organic substance • odontogenesis of dentin-containing tooth • spongiotrophoblast layer development • female pregnancy • response to wounding • cAMP biosynthetic process • antimicrobial humoral immune response mediated by antimicrobial peptide • positive regulation of blood vessel diameter • regulation of systemic arterial blood pressure • positive regulation of heart rate • regulation of urine volume Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	133	11535
Ensembl	ENSG00000148926	ENSMUSG00000030790
UniProt	P35318	P97297
RefSeq (mRNA)	NM_001124	NM_009627
RefSeq (protein)	NP_001115	NP_033757.1 NP_033757
Location (UCSC)	Chr 11: 10.3 – 10.31 Mb	Chr 7: 110.63 – 110.63 Mb
PubMed search

2FLY, 2L7S, 4RWF

133

11535

ENSG00000148926

ENSMUSG00000030790

P35318

P97297

NM_001124

NM_009627

NP_001115

NP_033757.1
NP_033757

Adrenomedullin (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was initially isolated in 1993 from a pheochromocytoma, a tumor of the adrenal medulla: hence the name.

In humans ADM is encoded by the ADM gene. ADM is a peptide expressed by all tissues, and found in the circulation. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.

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Wikipedia