RAMP2

RAMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RWF, 2XVT, 3AQE, 3AQF
Identifiers
Aliases	RAMP2, entrez:10266, receptor activity modifying protein 2
External IDs	OMIM: 605154 MGI: 1859650 HomoloGene: 4274 GeneCards: RAMP2
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 42,758,447 bp End 42,763,041 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 64.47 cM Start 101,246,028 bp End 101,259,546 bp
Gene ontology Molecular function • coreceptor activity • protein transporter activity • protein binding Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • receptor complex • integral component of plasma membrane • cell surface • clathrin-coated pit • lysosome Biological process • positive regulation of cAMP biosynthetic process • negative regulation of endothelial cell apoptotic process • G-protein coupled receptor signaling pathway • response to estradiol • response to hypoxia • regulation of G-protein coupled receptor protein signaling pathway • adherens junction assembly • response to progesterone • female pregnancy • receptor internalization • sprouting angiogenesis • basement membrane assembly • positive regulation of angiogenesis • vasculogenesis • regulation of blood pressure • heart development • cellular response to hormone stimulus • positive regulation of gene expression • positive regulation of vasculogenesis • angiogenesis • bicellular tight junction assembly • transport • protein transport • cellular response to vascular endothelial growth factor stimulus • intracellular protein transport • protein localization to plasma membrane • vascular smooth muscle cell development • calcium ion transport • negative regulation of vascular permeability • cAMP biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10266	54409
Ensembl	ENSG00000131477	ENSMUSG00000001240
UniProt	O60895	Q9WUP0
RefSeq (mRNA)	NM_005854	NM_019444
RefSeq (protein)	NP_005845	NP_062317
Location (UCSC)	Chr 17: 42.76 – 42.76 Mb	Chr 17: 101.25 – 101.26 Mb
PubMed search

4RWF, 2XVT, 3AQE, 3AQF

10266

54409

ENSG00000131477

ENSMUSG00000001240

O60895

Q9WUP0

NM_005854

NM_019444

NP_005845

NP_062317

Receptor activity modifying protein 2, also known as RAMP2, is a protein which in humans is encoded by the RAMP2 gene.

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N-terminus and a cytoplasmic C-terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

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Wikipedia