Glucagon receptor

GCGR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CZF, 4ERS, 4L6R, 2A83, 4LF3, 5EE7
Identifiers
Aliases	GCGR, GGR, GL-R, glucagon receptor
External IDs	OMIM: 138033 MGI: 99572 HomoloGene: 131 GeneCards: GCGR
Gene ontology Molecular function • G-protein coupled receptor activity • guanyl-nucleotide exchange factor activity • signal transducer activity • peptide hormone binding • glucagon receptor activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • endosome • membrane • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • glucose homeostasis • response to nutrient • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • cellular response to glucagon stimulus • generation of precursor metabolites and energy • regulation of glycogen metabolic process • regulation of blood pressure • cell surface receptor signaling pathway • hormone-mediated signaling pathway • response to starvation • signal transduction • exocytosis • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2642	14527
Ensembl	ENSG00000215644	ENSMUSG00000025127
UniProt	P47871	Q61606
RefSeq (mRNA)	NM_000160	NM_008101
RefSeq (protein)	NP_000151	NP_032127.2 NP_032127
Location (UCSC)	Chr 17: 81.8 – 81.81 Mb	Chr 11: 120.53 – 120.54 Mb
PubMed search

3CZF, 4ERS, 4L6R, 2A83, 4LF3, 5EE7

2642

14527

ENSG00000215644

ENSMUSG00000025127

P47871

Q61606

NM_000160

NM_008101

NP_000151

NP_032127.2
NP_032127

The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, G_s and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene.

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