HLA B7-DR15-DQ6
| Multi-gene haplotype, human | |||
|---|---|---|---|
 |
|||
| HLA region on chromosome 6 | |||
| HLA A3-B7-DR15-DQ6 | |||
| Loci | Gene | Allele | Serotype |
|
Class I centromeric |
HLA-C | *0702 | Cw7 |
| HLA-B | *0702 | B7 | |
| HLA-DR | HLA-DRB1 | *1501 | DR15 |
| HLA-DRB5 | *0101 | DR51 | |
| HLA-DQ | HLA-DQA1 | *0102 | DQ1 |
| HLA-DQB1 | *0602 | DQ6 | |
| Nodes | |||
| PopulationMaxima | Freq.Max | ||
| Western Ireland | 6.0% | ||
| Size and location | |||
| Genes | Location | size (kbps) | |
| - | 6 | 6p21.3 | 2500 |
HLA B7-DR15-DQ6 is a multigene that covers a majority of the human on chromosome 6. A multigene haplotype is set of inherited covering several genes, or gene-alleles, common multigene haplotypes are generally the result of descent by common ancestry (share a recent common ancestor for that segment of the chromosome). Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations.
HLA B7-DR15-DQ6 is a representation(by serotype) of a common HLA haplotype found in Western Eurasia. The haplotype can be written in an extended form covering the major histocompatibility loci as follows:
HLA Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602
The older literature may describe this haplotype in two different ways. One B7-DR2-DQ6 derives from the fact that DR15 is a split antigen of the DR2 broad antigen serotype. The other B7-DR2-DQ1 stems from the fact that DQ1 is an alpha chain serotype that is now covered by the beta chain type DQ5 and DQ6 (DQ1 pairs with DQ5 and DQ6 by cis-haplotype pairing).
There are two major subhaplotypes one that is preceded on its telomeric side by HLA A*0301 and the other by HLA A*0201. The A*0301 bearing haplotype (HLA A3-B7-DR15-DQ6) is described as the longest known multgene haplotype in humans.
The appendation of the B7::DQ6 haplotype creates the A2-B7::DQ6 haplotype. This haplotype if found often in Northern Spain, Switzerland, Netherlands.
HLA A*0201Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602
The gene-allele representation of the haplotype is:
HLA A*0301Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602
This is considered now the longest of the widely distributed ancestral haplotypes, its length is 4.8 million nucleotides and extends from TRIM27 gene . . . .The haplotype is nodal in Ireland but is also at high frequency in Switzerland, it has a subnode in the Pasiegos of northern Spain. There is some variance in the distribution of A3::DQ6 relative to A1::DQ2 in that there is more of a bias toward central and eastern Europe. Parts of the haplotype are spread into East Asia and even appear within the New world's indigeonous populations. DR15:DQ6 frequencies peak in central Asia, and it is suspect that this may be a point of Eurasian spread westward into Europe.
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Wikipedia