HLA-DRB1

HLA-DRB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1BX2, 1YMM, 2WBJ,%%s1A6A,%%s1AQD, 1DLH, 1FYT, 1HXY, 1JWM, 1JWS, 1JWU, 1KG0, 1KLG, 1KLU, 1LO5, 1PYW, 1R5I, 1SEB, 1SJH, 1T5W, 1T5X, 2FSE, 2G9H, 2IAM, 2IAN, 2ICW, 2IPK, 2OJE, 2XN9, 3L6F, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 3S4S, 3S5L, 4AEN, 4AH2, 4C56, 4E41, 4FQX, 4GBX, 4I5B, 4OV5, 4X5W, 4X5X,%%s1D5M, 1D5X, 1D5Z, 1D6E, 1J8H, 2SEB, 3O6F, 3T0E, 4IS6, 4MCY, 4MCZ, 4MD0, 4MD4, 4MD5, 4MDI, 4MDJ, 4Y19, 4Y1A
Identifiers
Aliases	HLA-DRB1, DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1, major histocompatibility complex, class II, DR beta 1
External IDs	HomoloGene: 136635 GeneCards: HLA-DRB1
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 32,578,769 bp End 32,589,848 bp
Gene ontology Molecular function • peptide antigen binding • MHC class II protein complex binding • virus receptor activity • MHC class II receptor activity • protein binding • CD4 receptor binding Cellular component • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endosome • Golgi apparatus • trans-Golgi network membrane • endoplasmic reticulum membrane • membrane • late endosome membrane • Golgi membrane • plasma membrane • transport vesicle membrane • MHC class II protein complex • cell surface • lysosomal membrane • endoplasmic reticulum • ER to Golgi transport vesicle membrane • lysosome • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane • extracellular exosome • external side of plasma membrane • integral component of plasma membrane • extracellular space Biological process • antigen processing and presentation • polysaccharide assembly with MHC class II protein complex • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response • T cell receptor signaling pathway • immunoglobulin production involved in immunoglobulin mediated immune response • humoral immune response mediated by circulating immunoglobulin • peptide antigen assembly with MHC class II protein complex • negative regulation of interferon-gamma production • inflammatory response to antigenic stimulus • protein tetramerization • regulation of interleukin-4 production • negative regulation of T cell proliferation • T-helper 1 type immune response • viral entry into host cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • viral process • regulation of interleukin-10 secretion • negative regulation of inflammatory response to antigenic stimulus • signal transduction • positive regulation of protein phosphorylation • positive regulation of kinase activity • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of MAPK cascade • positive regulation of monocyte differentiation • positive regulation of transcription, DNA-templated • positive regulation of viral entry into host cell • protein heterotetramerization • positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3123	n/a
Ensembl	ENSG00000236884 ENSG00000206240 ENSG00000229074 ENSG00000196126 ENSG00000206306 ENSG00000228080	n/a
UniProt	P01911 P01912 P04229 P20039 Q29974 Q30134 Q5Y7A7 Q95IE3 Q9GIY3 P13761 Q9TQE0 Q30167 P13760	n/a
RefSeq (mRNA)	NM_001243965 NM_002124 NM_001359193 NM_001359194	n/a
RefSeq (protein)	NP_001230894 NP_002115 NP_001346122 NP_001346123 NP_001230894.1 NP_002115.2	n/a
Location (UCSC)	Chr 6: 32.58 – 32.59 Mb	n/a
PubMed search		n/a

1BX2, 1YMM, 2WBJ,%%s1A6A,%%s1AQD, 1DLH, 1FYT, 1HXY, 1JWM, 1JWS, 1JWU, 1KG0, 1KLG, 1KLU, 1LO5, 1PYW, 1R5I, 1SEB, 1SJH, 1T5W, 1T5X, 2FSE, 2G9H, 2IAM, 2IAN, 2ICW, 2IPK, 2OJE, 2XN9, 3L6F, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 3S4S, 3S5L, 4AEN, 4AH2, 4C56, 4E41, 4FQX, 4GBX, 4I5B, 4OV5, 4X5W, 4X5X,%%s1D5M, 1D5X, 1D5Z, 1D6E, 1J8H, 2SEB, 3O6F, 3T0E, 4IS6, 4MCY, 4MCZ, 4MD0, 4MD4, 4MD5, 4MDI, 4MDJ, 4Y19, 4Y1A

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