HLA-C

HLA-C
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3BZF,%%s4NT6,%%s1EFX,%%s1IM9, 1QQD
Identifiers
Aliases	HLA-C, D6S204, HLA-JY3, HLC-C, PSORS1, major histocompatibility complex, class I, C, MHC
External IDs	OMIM: 142840 HomoloGene: 133080 GeneCards: HLA-C
Genetically Related Diseases
chronic obstructive pulmonary disease, psoriatic arthritis
Gene ontology Molecular function • peptide antigen binding • protein binding • receptor binding • TAP binding Cellular component • integral component of membrane • phagocytic vesicle membrane • Golgi apparatus • early endosome membrane • membrane • Golgi membrane • plasma membrane • cell surface • endoplasmic reticulum • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • extracellular exosome • secretory granule membrane • recycling endosome membrane • integral component of plasma membrane • extracellular region Biological process • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • immune system process • interferon-gamma-mediated signaling pathway • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • type I interferon signaling pathway • immune response • regulation of immune response • viral process • neutrophil degranulation • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3107	n/a
Ensembl	n/a	n/a
UniProt	P10321 Q29963 Q95604 Q07000 P30508 Q29960 P30499 Q9TNN7 Q29865 P30510 P30505 P04222 P30501 P30504	n/a
RefSeq (mRNA)	NM_002117 NM_001243042	n/a
RefSeq (protein)	NP_001229971 NP_002108	n/a
Location (UCSC)	Chr 6: 31.27 – 31.27 Mb	n/a
PubMed search		n/a

3BZF,%%s4NT6,%%s1EFX,%%s1IM9, 1QQD

3107

n/a

n/a

n/a

Q29960
P30499
Q9TNN7
Q29865
P30510
P30505
P04222
P30501
P30504

n/a

NM_002117
NM_001243042

n/a

NP_001229971
NP_002108

n/a

HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

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Wikipedia