HLA-DQA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1JK8, 1S9V, 2NNA, 4GG6, 4OZF, 4OZG, 4OZH, 4OZI

Identifiers

Aliases

HLA-DQA1, CD, CELIAC1, DQ-A1, GSE, HLA-DQA, HLA-DQA1, Major histocompatibility complex, class II, DQ alpha 1

External IDs

MGI: 95895 HomoloGene: 123820 GeneCards: HLA-DQA1

Genetically Related Diseases

asthma, membranous glomerulonephritis, chronic lymphocytic leukemia, systemic lupus erythematosus, celiac disease

Gene ontology
Molecular function	• peptide antigen binding • MHC class II receptor activity
Cellular component	• integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endosome • Golgi apparatus • trans-Golgi network membrane • endoplasmic reticulum membrane • membrane • Golgi membrane • plasma membrane • transport vesicle membrane • integral component of plasma membrane • MHC class II protein complex • lysosomal membrane • endoplasmic reticulum • ER to Golgi transport vesicle membrane • lysosome • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane
Biological process	• antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response • T cell receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3117


14960

Ensembl


n/a


ENSMUSG00000036594

UniProt


P01909

P14434 P14437 P01910 P14435 P14438
P04228 P14436 P04227

RefSeq (mRNA)


NM_002122


NM_010378

RefSeq (protein)


NP_002113


NP_034508.2 NP_034508

Location (UCSC)

Chr 6: 32.63 – 32.65 Mb

Chr 17: 34.28 – 34.29 Mb

PubMed search

1JK8, 1S9V, 2NNA, 4GG6, 4OZF, 4OZG, 4OZH, 4OZI

n/a

NP_034508.2
NP_034508

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

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