HLA-Cw7
| HLA-Cw7 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (MHC Class I, C cell surface antigen) | ||||||||||||||||
| About | ||||||||||||||||
| Protein | transmembrane receptor/ligand | |||||||||||||||
| Structure | αβ heterodimer | |||||||||||||||
| Subunits | HLA-Cw*07--, β2-microglobulin | |||||||||||||||
| Older names | - | |||||||||||||||
| Subtypes | ||||||||||||||||
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| Alleles link-out to IMGT/HLA database at EBI | ||||||||||||||||
|
Subtype
|
allele
|
Available structures
|
|---|---|---|
| Cw7 | *0701 | |
| - | *0702 | |
| {{{cNick3}}} | *07{{{cAllele3}}} | |
| {{{cNick4}}} | *07{{{cAllele4}}} |
| Study population |
Freq. (in %) |
|---|---|
| Cameroon Pygmy Baka | 25.0 |
| Ireland South | 21.2 |
| German Essen | 20.9 |
| Cameroon Sawa | 19.2 |
| Ireland Northern | 18.7 |
| France West | 18.1 |
| Kenya | 17.8 |
| Burkina Faso Fulani | 17.4 |
| Australia New South Wales | 17.3 |
| France South East | 17.3 |
| Morocco 'Berber' Nador Me… | 16.7 |
| Sudanese | 16.5 |
| United Kingdom Caucasians | 16.1 |
| Uganda Kampala | 16.0 |
| Brazil | 15.6 |
| USA Caucasian (2) | 15.5 |
| Kenya Nandi | 15.2 |
| Pakistan Baloch | 15.2 |
| Burkina Faso Rimaibe | 14.9 |
| Finland | 14.4 |
| Czech Republic | 14.2 |
| Swiss Geneva | 13.6 |
| South Africa Natal Tamil | 13.5 |
| Cameroon Bamileke | 13.0 |
| India Khandesh Pawra | 13.0 |
| Cameroon Beti | 12.9 |
| Tunisia | 12.6 |
| India New Delhi | 12.5 |
| Saudi Arabia Guraiat and … | 12.3 |
| Turkey | 12.3 |
| Zambia Lusaka | 12.2 |
| Kenya Luo | 11.7 |
| Burkina Faso Mossi | 11.3 |
| South Korea (1) | 11.1 |
| Spain Eastern Andalusia | 11.0 |
| USA Hispanic | 10.9 |
| Lebanon | 10.8 |
| India Tamil Nadu Nadar | 10.7 |
| Zimbabwe Harare Shona | 10.6 |
| Russia Arkhangelsk Pomors | 10.0 |
| Georgia Tibilisi Georgian… | 9.8 |
| Mexico Zaptotec Oaxaca | 9.7 |
| Israel Arab Druse | 9.0 |
| Senegal Niokholo Mandenka | 8.7 |
| USA North American Native… | 8.6 |
| Pakistan Sindhi | 8.3 |
| India North Delhi | 8.0 |
| Iran Baloch | 7.8 |
| Thailand | 7.7 |
| Singapore Riau Malay | 7.5 |
| India West Coast Parsis | 7.0 |
| Georgia Tibilisi Kurds | 6.9 |
| Pakistan Kalash | 6.5 |
| Mali Bandiagara | 6.2 |
| Pakistan Burusho | 5.6 |
| Pakistan Karachi Parsi | 5.5 |
| Pakistan Pathan | 5.5 |
| Russia Murmansk Saomi | 4.0 |
| Singapore Javanese Indone… | 4.0 |
| India Mumbai Marathas | 3.7 |
| Australia Indig. Cape Yor… | 3.4 |
| Pakistan Brahui | 3.4 |
| India West Bhils | 3.0 |
| China North Han | 2.9 |
| Jordan Amman | 2.8 |
| China Inner Mongolia | 2.5 |
| Italy North Pavia | 2.5 |
| Russia Nenets | 2.4 |
| China Qinghai Hui | 2.3 |
| Australia Indig. Groote E… | 2.1 |
| Russia Tuva (2) | 2.0 |
| USA Hawaii Okinawa | 1.9 |
| USA Asian | 1.8 |
| China South Han | 1.6 |
| China Beijing | 1.5 |
| Papua New Guinea Wanigela | 1.4 |
| Allele frequencies presented, only | |
| Study population |
Freq. (in %) |
|---|---|
| Venezuela Sierra de Perij… | 71.4 |
| PNG New Britain Rabaul | 57.1 |
| Mexico Mixtec Oaxaca | 33.3 |
| China Yunnan Lisu | 32.9 |
| Taiwan Taroko | 31.8 |
| China Yunnan Nu | 30.7 |
| Venezuela Perja Mountain … | 30.3 |
| PNG Madang | 30.2 |
| Mexico Zaptotec Oaxaca | 28.4 |
| Taiwan Tsou | 27.5 |
| Mexico Mixe Oaxaca | 26.4 |
| Russia Arkhangelsk Pomors | 26.0 |
| Ch. Guangdong Meizhou H… | 25.8 |
| Pakistan Burusho | 25.5 |
| USA South Dakota Lakota S… | 24.4 |
| Russia Nenets | 23.8 |
| USA New Mexico Canoncito … | 23.2 |
| China South Han | 20.8 |
| Brazil Terena | 20.2 |
| China Guangzhou | 19.9 |
| USA Asian | 19.5 |
| Ireland Northern | 18.6 |
| Swiss Geneva | 18.2 |
| Taiwan Bunun | 17.8 |
| Ireland South | 17.4 |
| Singapore Javanese Indone… | 17.0 |
| Philippines Ivatan | 16.0 |
| Taiwan Rukai | 16.0 |
| Australia New South Wales | 15.8 |
| Finland | 15.6 |
| USA South Texas Hispanics | 15.6 |
| Pakistan Sindhi | 15.5 |
| United Kingdom Caucasians | 15.5 |
| Saudi Arabia Guraiat and … | 15.2 |
| Cameroon Pygmy Baka | 15.0 |
| India Tamil Nadu Nadar | 14.8 |
| Japan Central | 14.6 |
| Russia Murmansk Saomi | 14.0 |
| USA Hawaii Okinawa | 13.8 |
| China Beijing | 13.6 |
| China Tibetan | 13.3 |
| China Qinghai Hui | 13.2 |
| Thailand | 13.0 |
| USA North American Native… | 12.8 |
| China Inner Mongolia | 12.7 |
| Japan (3) | 12.7 |
| Pakistan Brahui | 12.5 |
| PNG Wanigela | 12.5 |
| USA Caucasian pop2 | 12.5 |
| USA Hispanic | 12.4 |
| Czech Republic | 12.3 |
| China North Han | 11.9 |
| Taiwan Paiwan | 11.8 |
| China Wuhan | 11.6 |
| Cameroon Sawa | 11.5 |
| Taiwan Siraya | 10.8 |
| Taiwan Ami | 10.7 |
| New Caledonia | 10.0 |
| India North Delhi | 9.9 |
| Australia Indig. Cape Yor… | 9.6 |
| Pakistan Pathan | 9.5 |
| France West | 9.4 |
| Iran Baloch | 9.4 |
| South Africa Natal Tamil | 9.4 |
| German Essen | 9.1 |
| Taiwan Puyuma | 9.0 |
| India New Delhi | 8.9 |
| Pakistan Kalash | 8.7 |
| India Mumbai Marathas | 8.6 |
| Russia Tuva pop 2 | 8.6 |
| South Korea (3) | 8.3 |
| American Samoa | 8.0 |
| Brazil | 8.0 |
| USA African American | 8.0 |
| France South East | 7.2 |
| Cameroon Bamileke | 7.1 |
| India West Bhils | 7.0 |
| Australia Indig. Yuendumu | 6.8 |
| Cameroon Beti | 6.6 |
| Georgia Tibilisi Georgian… | 6.5 |
| Uganda Kampala | 6.1 |
| Turkey | 6.0 |
| Spain Eastern Andalusia | 5.5 |
| PNG Wosera | 5.4 |
| Mali Bandiagara | 4.7 |
| Zimbabwe Harare Shona | 4.6 |
| Mexico Chihuahua State Ta… | 4.5 |
| Pakistan Baloch | 4.5 |
| Kenya | 4.4 |
| Zambia Lusaka | 4.4 |
| Lebanon | 4.1 |
| Israel Arab Druse | 4.0 |
| Kenya Luo | 3.8 |
| Tunisia | 3.6 |
| PNG Eastern Highlands Gor… | 3.5 |
| Sudanese | 3.5 |
| Georgia Tibilisi Kurds | 3.4 |
| Morocco 'Berber' Nador Me… | 3.2 |
| England London Ashkenazi … | 2.9 |
| Allele frequencies presented, only | |
HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw7 is determined by the antibody recognition of α7 subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M . Cw7 and Cw*07 are almost synonymous in meaning. Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7.
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