HLA-DRB5

HLA-DRB5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FV1, 1H15, 1HQR, 1ZGL
Identifiers
Aliases	HLA-DRB5, HLA-DRB, major histocompatibility complex, class II, DR beta 5, HLA-DRB5
External IDs	OMIM: 604776 MGI: 95901 HomoloGene: 101524 GeneCards: HLA-DRB5
Gene location (Human) Chr. Chromosome 6 (human) Band n/a Start 32,517,343 bp End 32,530,287 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band n/a Start 34,305,877 bp End 34,316,199 bp
Gene ontology Molecular function • peptide antigen binding Cellular component • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endosome • Golgi apparatus • trans-Golgi network membrane • endoplasmic reticulum membrane • membrane • late endosome membrane • Golgi membrane • plasma • transport vesicle membrane • MHC class II protein complex • lysosomal membrane • endoplasmic reticulum • ER to Golgi transport vesicle membrane • lysosome • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane • extracellular exosome Biological process • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response • T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3127	14969
Ensembl	ENSG00000198502	ENSMUSG00000060586
UniProt	Q30154	P04231 P04230 P18468 P18469 O78196 n/a
RefSeq (mRNA)	NM_002125	NM_010382
RefSeq (protein)	NP_002116	NP_034512
Location (UCSC)	Chr 6: 32.52 – 32.53 Mb	Chr 6: 34.31 – 34.32 Mb
PubMed search

1FV1, 1H15, 1HQR, 1ZGL

3127

14969

ENSG00000198502

ENSMUSG00000060586

Q30154

n/a

NM_002125

NM_010382

NP_002116

NP_034512

HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

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