HLA-DR15

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

DR15 is positively associated Goodpasture syndrome, early age onset multiple sclerosis,pernicious anaemia, sarcoidosis, hypocretin deficiency associated narcolepsy and a predisposition for postmenopausal osteoporosis.

DRB1*1501 is positively associated with Goodpasture syndrome,juvenile rheumatoid arthritis, allergic bronchopulmonary aspergillosis,multiple sclerosis,systemic lupus erythematosus, cervical cancer (human papillomavirus infection), and Sjogren's syndrome associated with systemic lupus erythematosus.

DRB1*1502 is associated with systemic lupus erythematosus,systemic sclerosis (SSc) & anti-topoisomerase antibodies.

DRB1*1503 is associated with Chaga's cardiomyopathy, allergic bronchopulmonary aspergillosis,multiple sclerosis,cervical cancer (human papillomavirus infection).

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