Androgen receptor

AR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E3G, 1GS4, 1T5Z, 1T63, 1T65, 1XJ7, 1XOW, 1XQ3, 1Z95, 2AM9, 2AMA, 2AMB, 2AO6, 2AX6, 2AX7, 2AX8, 2AX9, 2AXA, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIU, 2PIV, 2PIW, 2PIX, 2PKL, 2PNU, 2Q7I, 2Q7J, 2Q7K, 2YHD, 2YLO, 2YLP, 2YLQ, 2Z4J, 3B5R, 3B65, 3B66, 3B67, 3B68, 3BTR, 3V49, 3V4A, 3ZQT, 4HLW, 3L3X, 3L3Z, 3RLJ, 3RLL, 4K7A, 4OEA, 4OED, 4OEY, 4OEZ, 4OFR, 4OFU, 4OGH, 4OH5, 4OH6, 4OHA, 4OIL, 4OIU, 4OJ9, 4OJB, 4OK1, 4OKB, 4OKT, 4OKW, 4OKX, 4OLM, 4QL8, 5CJ6
Identifiers
Aliases	AR, AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, androgen receptor
External IDs	OMIM: 313700 MGI: 88064 HomoloGene: 28 GeneCards: AR
Targeted by Drug
andarine, dihydrotestosterone, dromostanolone propionate, ethylestrenol, fluoxymesterone, metribolone, mibolerone, nandrolone, , methyltestosterone, bicalutamide, bisphenol A, cyproterone acetate, enzalutamide, flutamide, hydroxyflutamide, mifepristone, nilutamide
Gene ontology Molecular function • metal ion binding • lipid binding • receptor binding • sequence-specific DNA binding • RNA polymerase II transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein dimerization activity • chromatin binding • zinc ion binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • ATPase binding • androgen binding • steroid binding • transcription regulatory region DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • protein binding • DNA binding • beta-catenin binding • androgen receptor activity • POU domain binding • enzyme binding • transcription factor activity, sequence-specific DNA binding Cellular component • nucleoplasm • cytoplasm • cytosol • nucleus • nuclear chromatin • protein complex • plasma membrane Biological process • negative regulation of cell proliferation • positive regulation of cell differentiation • positive regulation of NF-kappaB transcription factor activity • sex differentiation • signal transduction • negative regulation of integrin biosynthetic process • cell-cell signaling • intracellular receptor signaling pathway • prostate gland development • positive regulation of integrin biosynthetic process • positive regulation of phosphorylation • regulation of establishment of protein localization to plasma membrane • androgen receptor signaling pathway • positive regulation of gene expression • positive regulation of cell proliferation • positive regulation of transcription, DNA-templated • transport • negative regulation of extrinsic apoptotic signaling pathway • steroid hormone mediated signaling pathway • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • cell proliferation • cell growth • positive regulation of transcription from RNA polymerase III promoter • protein oligomerization • transcription, DNA-templated • positive regulation of insulin-like growth factor receptor signaling pathway • male somatic sex determination • positive regulation of intracellular estrogen receptor signaling pathway • negative regulation of epithelial cell proliferation • regulation of gene expression • regulation of systemic arterial blood pressure • positive regulation of transcription from RNA polymerase II promoter • animal organ formation • multicellular organism growth • positive regulation of MAPK cascade • in utero embryonic development • reproductive system development • tertiary branching involved in mammary gland duct morphogenesis • cellular process • male gonad development • single fertilization • fertilization • regulation of prostatic bud formation • mammary gland alveolus development • epithelial cell differentiation involved in prostate gland development • epithelial cell morphogenesis • regulation of transcription from RNA polymerase II promoter • seminiferous tubule development • morphogenesis of an epithelial fold • prostate gland epithelium morphogenesis • Leydig cell differentiation • reproductive structure development • regulation of catalytic activity • regulation of developmental growth • lateral sprouting involved in mammary gland duct morphogenesis • male genitalia morphogenesis • prostate gland growth • activation of prostate induction by androgen receptor signaling pathway • spermatogenesis • protein deubiquitination • positive regulation of epithelial cell proliferation involved in prostate gland development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	367	11835
Ensembl	ENSG00000169083	ENSMUSG00000046532
UniProt	P10275	P19091
RefSeq (mRNA)	NM_001011645 NM_000044	NM_013476
RefSeq (protein)	NP_000035 NP_001011645 NP_001334990 NP_001334992 NP_001334993 NP_000035.2 NP_001011645.1	NP_038504.1 NP_038504
Location (UCSC)	Chr X: 67.54 – 67.73 Mb	Chr X: 98.15 – 98.32 Mb
PubMed search

Androgen_recep
crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor nh2-terminal peptide, ar20-30, and r1881
Identifiers
Symbol	Androgen_recep
Pfam	PF02166
InterPro	IPR001103
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1E3G, 1GS4, 1T5Z, 1T63, 1T65, 1XJ7, 1XOW, 1XQ3, 1Z95, 2AM9, 2AMA, 2AMB, 2AO6, 2AX6, 2AX7, 2AX8, 2AX9, 2AXA, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIU, 2PIV, 2PIW, 2PIX, 2PKL, 2PNU, 2Q7I, 2Q7J, 2Q7K, 2YHD, 2YLO, 2YLP, 2YLQ, 2Z4J, 3B5R, 3B65, 3B66, 3B67, 3B68, 3BTR, 3V49, 3V4A, 3ZQT, 4HLW, 3L3X, 3L3Z, 3RLJ, 3RLL, 4K7A, 4OEA, 4OED, 4OEY, 4OEZ, 4OFR, 4OFU, 4OGH, 4OH5, 4OH6, 4OHA, 4OIL, 4OIU, 4OJ9, 4OJB, 4OK1, 4OKB, 4OKT, 4OKW, 4OKX, 4OLM, 4QL8, 5CJ6