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Alpha-2C adrenergic receptor

ADRA2C
Protein ADRA2C PDB 1hll.png
Identifiers
Aliases ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, adrenoceptor alpha 2C
External IDs MGI: 87936 HomoloGene: 20170 GeneCards: ADRA2C
Targeted by Drug
apraclonidine, guanabenz, dexmedetomidine, norepinephrine, brimonidine, clonidine, guanfacine, oxymetazoline, pergolide, xylazine, apomorphine, brl-44408, bromocriptine, cabergoline, chlorpromazine, lisuride, lurasidone, mirtazapine, phentolamine, piribedil, prazosin, α-yohimbine, roxindole, spiroxatrine, terguride, tolazoline, WB-4101, yohimbine
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000683

NM_007418

RefSeq (protein)

NP_000674

NP_031444.2
NP_031444

Location (UCSC) Chr 4: 3.77 – 3.77 Mb Chr 5: 35.28 – 35.28 Mb
PubMed search

NM_000683

NM_007418

NP_000674

NP_031444.2
NP_031444

The alpha-2C adrenergic receptor2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity.


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Wikipedia

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