Alpha-2B adrenergic receptor

ADRA2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CVA
Identifiers
Aliases	ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR, FAME2, adrenoceptor alpha 2B
External IDs	MGI: 87935 HomoloGene: 553 GeneCards: ADRA2B
Targeted by Drug
guanabenz, dexmedetomidine, guanfacine, brimonidine, clonidine, norepinephrine, oxymetazoline, pergolide, xylazine, apomorphine, brl-44408, bromocriptine, cabergoline, chlorpromazine, lisuride, mirtazapine, phenoxybenzamine, phentolamine, prazosin, α-yohimbine, roxindole, spiroxatrine, terguride, tolazoline, WB-4101, yohimbine, zotepine
Gene ontology Molecular function • G-protein coupled receptor activity • epinephrine binding • signal transducer activity • adrenergic receptor activity • protein binding • alpha2-adrenergic receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • activation of protein kinase B activity • negative regulation of epinephrine secretion • regulation of smooth muscle contraction • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway • cell-cell signaling • activation of MAPK activity by adrenergic receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of vasoconstriction • positive regulation of neuron differentiation • signal transduction • platelet activation • negative regulation of norepinephrine secretion • female pregnancy • positive regulation of blood pressure • adrenergic receptor signaling pathway • activation of MAPK activity • regulation of vascular smooth muscle contraction • positive regulation of uterine smooth muscle contraction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151	11552
Ensembl	ENSG00000274286	ENSMUSG00000058620
UniProt	P18089	P30545
RefSeq (mRNA)	NM_000682	NM_009633
RefSeq (protein)	NP_000673 NP_000673.2	n/a
Location (UCSC)	Chr 2: 96.11 – 96.12 Mb	Chr 2: 127.36 – 127.37 Mb
PubMed search

2CVA

151

11552

ENSG00000274286

ENSMUSG00000058620

P18089

P30545

NM_000682

NM_009633

NP_000673
NP_000673.2

n/a

The alpha-2B adrenergic receptor (α_2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic receptor family. The human gene encoding this receptor has the symbol ADRA2B. ADRA2B orthologs have been identified in several mammals.

α₂-adrenergic receptors include 3 highly homologous subtypes: α_2A, α_2B, and α_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

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Wikipedia