Alpha-2A adrenergic receptor

ADRA2A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1HLL, 1HO9, 1HOD, 1HOF

Identifiers

Aliases

ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A

External IDs

MGI: 87934 HomoloGene: 47944 GeneCards: ADRA2A

Targeted by Drug

apraclonidine, guanabenz, epinephrine, brimonidine, norepinephrine, apomorphine, clonidine, dexmedetomidine, guanfacine, oxymetazoline, pergolide, xylazine, brl-44408, bromocriptine, cabergoline, chlorpromazine, lisuride, lurasidone, mirtazapine, phentolamine, piribedil, prazosin, α-yohimbine, spiroxatrine, terguride, tolazoline, WB-4101, yohimbine

Gene ontology
Molecular function	• alpha-2C adrenergic receptor binding • G-protein coupled receptor activity • protein homodimerization activity • epinephrine binding • norepinephrine binding • alpha-1B adrenergic receptor binding • signal transducer activity • adrenergic receptor activity • protein binding • alpha2-adrenergic receptor activity • protein heterodimerization activity • thioesterase binding • heterotrimeric G-protein binding • protein kinase binding
Cellular component	• integral component of membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane • basolateral plasma membrane • cytoplasm
Biological process	• G-protein coupled receptor signaling pathway • positive regulation of epidermal growth factor-activated receptor activity • negative regulation of adenylate cyclase activity • movement of cell or subcellular component • activation of protein kinase B activity • negative regulation of insulin secretion • positive regulation of MAP kinase activity • negative regulation of epinephrine secretion • glucose homeostasis • regulation of smooth muscle contraction • positive regulation of cytokine production • regulation of insulin secretion • positive regulation of cell migration • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway • positive regulation of potassium ion transport • phospholipase C-activating adrenergic receptor signaling pathway • positive regulation of wound healing • negative regulation of norepinephrine secretion • positive regulation of membrane protein ectodomain proteolysis • negative regulation of insulin secretion involved in cellular response to glucose stimulus • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • negative regulation of calcium ion transmembrane transporter activity • activation of MAPK activity by adrenergic receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • cellular response to hormone stimulus • regulation of vasoconstriction • negative regulation of calcium ion-dependent exocytosis • Rho protein signal transduction • positive regulation of cell proliferation • negative regulation of cAMP biosynthetic process • negative regulation of calcium ion transport • intestinal absorption • negative regulation of adrenergic receptor signaling pathway • Ras protein signal transduction • negative regulation of lipid catabolic process • activation of protein kinase activity • actin cytoskeleton organization • signal transduction • platelet activation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


150


11551

Ensembl


ENSG00000150594


ENSMUSG00000033717

UniProt


P08913


Q01338

RefSeq (mRNA)


NM_000681


NM_007417

RefSeq (protein)


NP_000672


n/a

Location (UCSC)

Chr 10: 111.08 – 111.08 Mb

Chr 19: 54.05 – 54.05 Mb

PubMed search

1HLL, 1HO9, 1HOD, 1HOF

n/a

The alpha-2A adrenergic receptor (α_2A adrenoceptor), also known as ADRA2A, is an α₂ adrenergic receptor, and also denotes the human gene encoding it.

α₂ adrenergic receptors include 3 highly homologous subtypes: α_2A, α_2B, and α_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α_2A and α_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α_2C subtype modulated neurotransmission at lower levels of nerve activity.

...
Wikipedia