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Fatty acid


In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with a long aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, from 4 to 28. Fatty acids are usually derived from triglycerides or phospholipids. Fatty acids are important sources of fuel because, when metabolized, they yield large quantities of ATP. Many cell types can use either glucose or fatty acids for this purpose. Long-chain fatty acids cannot cross the blood–brain barrier (BBB) and so cannot be used as fuel by the cells of the central nervous system; however, free short-chain fatty acids and medium-chain fatty acids can cross the BBB, in addition to glucose and ketone bodies.

Fatty acids that have carbon–carbon double bonds are known as unsaturated. Fatty acids without double bonds are known as saturated. They differ in length as well.

Fatty acid chains differ by length, often categorized as short to very long.

Unsaturated fatty acids have one or more double bonds between carbon atoms. (Pairs of carbon atoms connected by double bonds can be saturated by adding hydrogen atoms to them, converting the double bonds to single bonds. Therefore, the double bonds are called unsaturated.)

The two carbon atoms in the chain that are bound next to either side of the double bond can occur in a cis or trans configuration.



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Federation of European Nutrition Societies


imageFederation of European Nutrition Societies (FENS)

The Federation of European Nutrition Societies (FENS) is a non-profit association, established in 1979 as a roof organization for the national nutrition societies in Europe, with each country represented by its representative Nutrition Society or Association within FENS.

The aims of FENS are the combination of efforts for the development of research and education in Nutrition Sciences and the promotion of the importance of Nutrition for public health in Europe. It seeks to do this by coordinating the European nutrition societies at a European level, promoting and disseminating research and knowledge on nutrition sciences and facilitating nutrition learning and training, as well as scientific exchange across Europe.

FENS conducts every 4 years its main event, the FENS European Nutrition Conference, which is organized by one of the FENS member societies, elected by the FENS General Assembly. All FENS Member Societies and Associations can take part in the bidding process for the organization of a FENS ENC.

The Federation of European Nutrition Societies is a member of the International Union of Nutritional Sciences (IUNS) and the official FENS Journal is the “Annals of Nutrition and Metabolism” (IF 2014/2015: 2.618)



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Flavan-3-ol


Flavan-3-ols (sometimes referred to as flavanols) are derivatives of flavans that use the 2-phenyl-3,4-dihydro-2H-chromen-3-ol skeleton. These compounds include catechin, epicatechin gallate, epigallocatechin, epigallocatechin gallate, proanthocyanidins, theaflavins, thearubigins.

Flavanols (with an "a") are not to be confused with flavonols (with an "o"), a class of flavonoids containing a ketone group.

The single-molecule (monomer) catechin, or isomer epicatechin (see diagram), adds four hydroxyls to flavan-3-ol, making building blocks for concatenated polymers (proanthocyanidins) and higher order polymers (anthocyanidins).

Flavanols possess two chiral carbons, meaning four diastereoisomers occur for each of them.

Catechins are distinguished from the yellow, ketone-containing flavonoids such as quercitin and rutin, which are called flavonols. Early use of the term bioflavonoid was imprecisely applied to include the flavanols, which are distinguished by absence of ketone(s). Catechin monomers, dimers, and trimers (oligomers) are colorless. Higher order polymers, anthocyanidins, exhibit deepening reds and become tannins.

The catechins are abundant in teas derived from the tea plant Camellia sinensis, as well as in some cocoas and chocolates (made from the seeds of Theobroma cacao).



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Flavonoid


Flavonoids (or bioflavonoids) (from the Latin word flavus meaning yellow, their color in nature) are a class of plant and fungus secondary metabolites.

Chemically, flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and heterocyclic ring (C). This carbon structure can be abbreviated C6-C3-C6. According to the IUPAC nomenclature, they can be classified into:

The three flavonoid classes above are all ketone-containing compounds, and as such, are anthoxanthins (flavones and flavonols). This class was the first to be termed bioflavonoids. The terms flavonoid and bioflavonoid have also been more loosely used to describe non-ketone polyhydroxy polyphenol compounds which are more specifically termed flavanoids. The three cycle or heterocycles in the flavonoid backbone are generally called ring A, B and C. Ring A usually shows a phloroglucinol substitution pattern.

Flavonoids are widely distributed in plants, fulfilling many functions. Flavonoids are the most important plant pigments for flower coloration, producing yellow or red/blue pigmentation in petals designed to attract pollinator animals. In higher plants, flavonoids are involved in UV filtration, symbiotic nitrogen fixation and floral pigmentation. They may also act as chemical messengers, physiological regulators, and cell cycle inhibitors. Flavonoids secreted by the root of their host plant help Rhizobia in the infection stage of their symbiotic relationship with legumes like peas, beans, clover, and soy. Rhizobia living in soil are able to sense the flavonoids and this triggers the secretion of Nod factors, which in turn are recognized by the host plant and can lead to root hair deformation and several cellular responses such as ion fluxes and the formation of a root nodule. In addition, some flavonoids have inhibitory activity against organisms that cause plant diseases, e.g. Fusarium oxysporum.



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Fluid balance


Fluid balance is an aspect of the homeostasis of living organisms in which the amount of water in the organism needs to be controlled, via osmoregulation and behavior, such that the concentrations of electrolytes (salts in solution) in the various body fluids are kept within healthy ranges. The core principle of fluid balance is that the amount of water lost from the body must equal the amount of water taken in; for example, in human homeostasis, the output (via respiration, perspiration, urination, defecation, and expectoration) must equal the input (via eating, drinking, and parenteral intake). Euvolemia is the state of normal body fluid volume, including blood volume, interstitial fluid volume, and intracellular fluid volume; hypovolemia and hypervolemia are imbalances. Water is necessary for all life on Earth. Humans can survive for 4 to 6 weeks without food but only for a few days without water.

Profuse sweating can increase the need for electrolyte replacement. Water-electrolyte imbalance produces headache and fatigue if mild; illness if moderate, and sometimes even death if severe. For example, water intoxication (which results in hyponatremia), the process of consuming too much water too quickly, can be fatal. Deficits to body water result in volume contraction and dehydration. Diarrhea is a threat to both body water volume and electrolyte levels, which is why diseases that cause diarrhea are great threats to fluid balance.



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Food and diet in ancient medicine


Modern understanding of disease is very different from the way it was understood in ancient Greece and Rome. The way modern physicians approach healing of the sick differs greatly from the methods used by early general healers or elite physicians like Hippocrates or Galen. In modern medicine, the understanding of disease stems from the “germ theory of disease”, a concept that emerged in the second half of the 19th century, such that a disease is the result of an invasion of a microorganism into a living host. Therefore, when a person becomes ill, modern treatments “target” the specific pathogen or bacterium in order to “beat” or “kill” the disease. In Ancient Greece and Rome, disease was literally understood as dis-ease, or physical imbalance. Medical intervention, therefore, was purposed with goal of restoration of harmony rather than waging a war against disease. Surgery was regarded by Greek and Roman physicians as extreme and damaging while prevention was seen as the crucial first step to healing almost all ailments. In both prevention and treatment of disease in classical medicine, food and diet was central. The eating of correctly-balanced foods made up the majority of preventative treatment as well as to restore harmony to the body after it encountered disease.

Ancient Greek Medicine is described as rational, ethical and based upon observation, conscious learning and experience. Superstition and religious dogmatism are often excluded from descriptions of ancient Greek medicine. It is important, however, to note that this rational approach to medicine did not always exist in the ancient Greek medical world, nor was it the only popular method of healing. Along with rational Greek medicine, disease was also thought of as being of supernatural origin, resulting from the unhappiness of the gods or from demonic possession. Exorcists and religious healers were among the ‘doctors’ that patients sought out when they became ill. Sacrifices, exorcisms, spells and prayers were then carried out in order to reconcile with the gods and restore health to the patient. It was not until the time of Hippocrates, between 450 and 350 BC, that rational, observation and the humoral theory of medicine began to become highly influential. The theory of the humours or “Humorism” understood the human body to be composed of fluid (humours) and regarded disease as a result of an imbalance of the four humors: yellow bile, black bile, phlegm and blood.

These humours contain qualities such as hot, cool, moist, dry, etc., which must also remain in balance. Foods can be heating, cooling, or generative of one humour. Some foods produce good juices and others bad juices and often times cooking and preparation of the foods can change or improve the juices of the foods. In addition, foods may be easy to assimilate (easy to pass through the body), easily excreted, nourishing or not nourishing. In Hippocratic medicine, the qualities in foods are analogous to the four humors in the body: too much of a single one is bad, a proper mixture is ideal. Therefore, the consumption of correctly-balanced foods and life-style of the patient was crucial to the prevention and treatment of disease in Ancient Greece.



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Food contaminant


Food contamination refers to the presence in food of harmful chemicals and microorganisms which can cause consumer illness. This article addresses the chemical contamination of foods, as opposed to microbiological contamination, which can be found under foodborne illness.

The impact of chemical contaminants on consumer health and well-being is often apparent only after many years of processing.Prolonged exposure at low levels (e.g., cancer). Chemical contaminants present in foods are often unaffected by thermal processing (unlike most microbiological agents). Chemical contaminants can be classified according to the source of contamination and the mechanism by which they enter the food product.

Agrochemicals are chemicals used in agricultural practices and animal husbandry with the intent to increase crops and reduce costs. Such agents include pesticides (e.g., insecticides, herbicides, rodenticides), plant growth regulators, veterinary drugs (e.g., nitrofuran, fluoroquinolones, malachite green, chloramphenicol), and bovine somatotropin (rBST).

Environmental contaminants are chemicals that are present in the environment in which the food is grown, harvested, transported, stored, packaged, processed, and consumed. The physical contact of the food with its environment results in its contamination. Possible sources of contamination include:

There are many cases of banned pesticides or carcinogens found in foods.

There is a heavy stigma attached to the presence of hair in food in most societies. There is a risk that it may induce choking and vomiting, and also that it may be contaminated by toxic substances. Views differ as to the level of risk it poses to the inadvertent consumer.



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Food composition data


Food composition data (FCD) are detailed sets of information on the nutritionally important components of foods and provide values for energy and nutrients including protein, carbohydrates, fat, vitamins and minerals and for other important food components such as fibre. The data are presented in food composition databases (FCDBs).

In the UK, FCD is listed in tables known as The Chemical Composition of Foods, McCance and Widdowson (1940) and in the first edition the authors stated that:

‘A knowledge of the chemical composition of foods is the first essential in the dietary treatment of disease or in any quantitative study of human nutrition’.

This demonstrates the main reason for establishing FCD at that time. To this day, food composition studies remain central to nutrition research into the role of food components and their interactions in health and disease. However, due to increasing levels of sophistication and complexity in nutrition science, there is a greater demand for complete, current and reliable FCD, together with information on a wider range of food components, including bioactive compounds.

FCD are important in many fields including clinical practice, research, nutrition policy, public health and education, and the food manufacturing industry and is used in a variety of ways including: national programmes for the assessment of diet and nutritional status at a population level (e.g. epidemiological researchers assessing diets at a population level); development of therapeutic diets (e.g. to treat obesity, diabetes, nutritional deficiencies, food allergy and intolerance) and institutional diets (e.g. schools, hospitals, prisons, day-care centres) and nutrition labelling of processed foods.

The earliest food composition tables were based solely on chemical analyses of food samples, which were mostly undertaken specifically for the tables. However, as the food supply has evolved, and with the increasing demand for nutritional and related components, it has become more difficult for compilers to rely only on chemical analysis when compiling FCDBs. For example, in the UK the third edition of The Composition of Foods presented data on vitamin content of foods. However, due to the amount of information already available and in order to avoid the need to analyse every food for every vitamin, values from the scientific literature were included, although the tables are still predominately based on analytical data. Nowadays, food composition databases tend to be compiled using a variety of methods, including:

Chemical analysis of food samples carried out in analytical laboratories is typically the preferred method for creating FCD. The food samples are carefully chosen using a defined sampling plan to ensure that they are representative of the foods being consumed in a country. This includes accounting for factors that could affect the nutrient content of a food as purchased (e.g. region and/or country of origin, season, brand, fortification) or as consumed (e.g. storage, preparation and cooking methods). If necessary, further preparation and cooking takes place prior to the analysis using appropriate analytical methods and often appropriate samples of foods are combined rather than taking averages of individually analysed food samples. Ideally, the methods used for analysis should have been shown to be reliable and reproducible, i.e. those recommended by organisation such as the Association of Official Analytical Chemists (AOAC) or the International Organisation for Standardisation (ISO).



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Food circle


A food circle is a visual nutrition guide in the form of a pie chart used to explain healthy nutrition. An example is the United States Department of Agriculture's MyPlate, which has replaced the USDA' s food pyramid promoted until 2011 (called "Food Guide Pyramid"). Developed under the Obama administration, MyPlate shows at a glance the groups and their recommended amounts. The logo is on cereal boxes and so forth. On the U.S. government's educational website about nutrition, the different parts of the logo are clickable, bringing the reader to different pages.



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Food energy


Food energy is chemical energy that animals (including humans) derive from their food and molecular oxygen through the process of cellular respiration. (Cellular respiration involves either the process of joining oxygen from air with the molecules of food (aerobic respiration) or the process of reorganizing the atoms within the molecules (anaerobic respiration).)

Humans and other animals need a minimum intake of food energy to sustain their metabolism and to drive their muscles. Foods are composed chiefly of carbohydrates, fats, proteins, water, vitamins, and minerals. Carbohydrates, fats, proteins, and water represent virtually all the weight of food, with vitamins and minerals making up only a small percentage of the weight. (Carbohydrates, fats, and proteins comprise ninety percent of the dry weight of foods.) Organisms derive food energy from carbohydrates, fats and proteins as well as from organic acids, polyols, and ethanol present in the diet. Some diet components that provide little or no food energy, such as water, minerals, vitamins, cholesterol, and fiber, may still be necessary to health and survival for other reasons. Water, minerals, vitamins, and cholesterol are not broken down (they are used by the body in the form in which they are absorbed) and so cannot be used for energy. Fiber, a type of carbohydrate, cannot be completely digested by the human body. Ruminants can extract food energy from the respiration of cellulose because of bacteria in their rumens.



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