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Cholesterol


imageCholesterol

Cholesterol, from the Ancient Greek chole- (bile) and stereos (solid) followed by the chemical suffix -ol for an alcohol, is an organic molecule. It is a sterol (or modified steroid), a type of lipid molecule, and is biosynthesized by all animal cells, because it is an essential structural component of all animal cell membranes; essential to maintain both membrane structural integrity and fluidity. Cholesterol enables animal cells to dispense with a cell wall (to protect membrane integrity and cell viability), thereby allowing animal cells to change shape and animals to move (unlike bacteria and plant cells, which are restricted by their cell walls).

In addition to its importance for animal cell structure, cholesterol also serves as a precursor for the biosynthesis of steroid hormones and bile acids. Cholesterol is the principal sterol synthesized by all animals. In vertebrates, hepatic cells typically produce the greatest amounts. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as Mycoplasma, which require cholesterol for growth.

François Poulletier de la Salle first identified cholesterol in solid form in gallstones in 1769. However, it was not until 1815 that chemist Michel Eugène Chevreul named the compound "cholesterine".



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List of cholesterol in foods


This list consists of common foods with their cholesterol content recorded in milligrams per 100 grams (3.5 ounces) of food.

Cholesterol is a sterol, a steroid-like hormone made by animals, including humans. The human body makes one-eighth to one-fourth teaspoons of pure cholesterol daily. A cholesterol level of 5.5 or below is recommended for an adult. The rise of cholesterol in the body can give a condition in which excessive cholesterol is deposited in artery walls called atherosclerosis. This condition blocks the blood flow to vital organs which can result in high blood pressure or stroke. Cholesterol is not always bad. There are some types of cholesterol which are beneficial to the heart and blood vessels. High-density lipoprotein is commonly called the "good" part of cholesterol. These lipoproteins help in the removal of cholesterol from the cells, which is then transported back to the liver where it is disintegrated and excreted as waste or broken down into parts.



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Ciberobn


The Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición: CIBERObn, www.ciberobn.com) is a public research consortium which was founded on November 28, 2006 financed by the Instituto de Salud Carlos III (ISCIII) and the Ministerio de Ciencia e Innovación (MICINN).

The CIBERObn gathers 25 investigation groups from different Spanish Hospitals, Universities and Research Centres. Its mission is to promote a better knowledge about the mechanisms contributing to obesity development in order to reduce its incidence and prevalence, as well as its complications, in addition to nutrition-related diseases. The CIBERObn is structured into 8 scientific programs intended to increase the collaboration between researchers, to strengthen synergies and to boost new research lines. Programs are as follows:

Additionally, CIBERObn lays a particular emphasis on translational research, specially focusing on research transfer to clinical applications and practices. To this end, two cross-cutting programs have been created:

The Fat Bank is a strategic platform of the CIBERobn which offers the Scientific Community different kinds of biological material which are associated to thorough metabolic phenotyping. This information is entered by means of a tailor-made individualised software. This fat-bank- launched in 2009- currently contains 3000 samples of biologic material from more than 300 individuals.

In 2009, 287 indexed articles were published. Their average impact factor is 4.05, which is very high for this subject area. Of them, 67 (23%) belong to the first decile and 105 more (total 172 papers, 60%) belong to the first quartile of the subject area of indexed journals. They accumulate a total impact factor of 1,165. Provisional data of 2010 show an increase of 10%, highly improving the international visibility of the consortium.



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Clinical nutrition


Clinical nutrition is nutrition of patients in health care. in this sense refers to the management of patients, including not only outpatients at clinics, but also (and mainly) inpatients in hospitals. It incorporates primarily the scientific fields of nutrition and dietetics. It aims to keep a healthy energy balance in patients, as well as providing sufficient amounts other nutrients such as protein, vitamins, minerals.

Among the routes of administration, the preferred means of nutrition is, if possible, oral administration. Alternatives include enteral administration (in nasogastric feeding) and intravenous (in parenteral nutrition).

In the field of clinical nutrition, malnutrition has causes, epidemiology and management distinct from those associated with malnutrition that is mainly related to poverty.

The main causes of clinical malnutrition are:

Clinical malnutrition may also be aggravated by iatrogenic factors, i.e., the inability of a health care entity to appropriately compensate for causes of malnutrition.

There are various definitions of clinical malnutrition. According to one of them, patients are defined as severely undernourished when meeting at least one of the following criteria: BMI < or = 20 kg/m2 and/or > or = 5% unintentional weight loss in the past month and/or > or = 10% unintentional weight loss in the past 6 months. By the same system, the patient is moderately undernourished if they met at least one of the following criteria: BMI 20.1–22 kg/m2 and/or 5-10% unintentional weight loss in the past six months.



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Complete protein


A complete protein (or whole protein) is a source of protein that contains an adequate proportion of all nine of the essential amino acids necessary for the dietary needs of humans or other animals.

According to the Food and Nutrition Board of the Institute of Medicine, complete proteins are supplied by meat, poultry, fish, eggs, milk, cheese, or yogurt. Since the amino acid profile of protein in plant food may be deficient in one or more of the following types, plant proteins are said to be incomplete. Vegetarian meals may supply complete protein by the practice of protein combining which raises the amino acid profile through plant variety.

The following table lists the optimal profile of the essential amino acids, which comprises complete protein, as recommended by the Institute of Medicine's Food and Nutrition Board:

The second column in the following table shows the amino acid requirements of adults as recommended by the World Health Organization calculated for a 62-kilogram (156 pounds) adult. Recommended Daily Intake is based on 2,000 kilocalories per day., which is also an appropriate daly calorie allowance for a fairly sendentary, 156-pound adult. The third column in the following table shows the amino acid profile of 2,000.14 kilocalories of baked potatoes (2,652 grams).

From the chart, you can see that if you ate nothing but baked potatoes all day, you would have plenty of every essential amino acid. Therefore, potatoes are a source of complete protein.

Nearly all whole foods contain all essential amino acids in sufficient quantity. The concept that plant proteins are incomplete or inferior has been dismissed by the nutrition community as myth. While many plant proteins are lower in one or more essential amino acids than animal proteins, especially lysine, and to a lesser extent methionine and threonine, eating a variety of plants can serve as a well-balanced and complete source of amino acids.

Consuming a mixture of plant-based protein sources can increase the biological value (BV) of food. For example, to obtain 25 grams of high BV protein requires 492 grams of canned pinto beans (USDA16044) for a total calorie intake of 423 kcal. When paired with 12 g of Brazil nuts (USDA12078), we require only 364 g of canned pinto beans, for a total of 391 kcal. This small addition of Brazil nuts yields a 23% reduction in the total food mass and a 7.5% reduction in calories. Complementary proteins need not be eaten at the same meal for your body to use them together. Your body can combine complementary proteins that are eaten over the course of the day.



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Conditioned satiety


Conditioned satiety is one of the three known food-specific forms of suppression of appetite for food by effects of eating, along with alimentary alliesthesia and sensory-specific satiety. Conditioned satiety was first evidenced in 1955 in rats by the late French physiologist professor Jacques Le Magnen. The term was coined in 1972 by professor David Allenby Booth. Unlike the other two sorts of stimulus-specific satiety, this phenomenon is based on classical conditioning but is distinct from conditioned taste aversion (CTA) in its dependence on internal state towards the end of a meal.

Conditioned satiety is thought to be acquired when a food with a given flavour is eaten on a partly full stomach and followed promptly by a mildly aversive digestive event ("bloat"). However, it is uncertain if and how this phenomenon may occur under real-life conditions as normally more than food of one given flavor is ingested during a meal. It has been widely misunderstood as an association of the sensory properties of a food with its energy content (calories) or carbohydrate content. However that is a confusion with the conditioning of simple aversion or a contrast with simple conditioned preference. Conditioned satiety has only been evidenced in experiments with rats, monkeys or humans when a flavour and fullness together have been paired with concentrated maltodextrin. When a whole meal of concentrated maltodextrin is eaten without changing its flavour, only the conditioning of preference for the flavour early in the meal is seen. Rats, monkeys and people can learn conditioned satiety within one or two pairings although in the first experiments the rats needed several days to adapt their intakes because the test food was aversively flavoured or textured. The particularity of conditioned satiety is that the time lapse between intake (and thus sensory stimulation) and the aversively conditioning after-effect is much shorter (less than 15 minutes) than that feasible for the conditioning of simple aversion to taste, odour or texture by poisoning, which can occur with a delay in postabsorptive effects of 12 or more hours.



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Copper in health


Copper is an essential trace element that is vital to the health of all living things (humans, plants, animals, and microorganisms). In humans, copper is essential to the proper functioning of organs and metabolic processes. The human body has complex homeostatic mechanisms which attempt to ensure a constant supply of available copper, while eliminating excess copper whenever this occurs. However, like all essential elements and nutrients, too much or too little nutritional ingestion of copper can result in a corresponding condition of copper excess or deficiency in the body, each of which has its own unique set of adverse health effects.

Daily dietary standards for copper have been set by various health agencies around the world. Standards adopted by some nations recommend different copper intake levels for adults, pregnant women, infants, and children, corresponding to the varying need for copper during different stages of life.

Copper deficiency and toxicity can be either of genetic or non-genetic origin. The study of copper's genetic diseases, which are the focus of intense international research activity, has shed insight into how human bodies use copper, and why it is important as an essential micronutrient. The studies have also resulted in successful treatments for genetic copper excess conditions, enabling patients whose lives were once jeopardized to live long and productive lives.

Researchers specializing in the fields of microbiology, toxicology, nutrition, and health risk assessments are working together to define the precise copper levels that are required for essentiality, while avoiding deficient or excess copper intakes. Results from these studies are expected to be used to fine-tune governmental dietary recommendation programs which are designed to help protect public health.



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CRNHs


imageCentres de Recherche en Nutrition Humaine

The CRNHs goal is to improve the knowledge on the function properties of food, on metabolism and on human physiology, from basic research to the study of behaviours and their impact on health. The French territory is now provided with four CRNH having common tools and complementary scientific skills that allow them to develop multi center programs using their platforms and their specific skills.

Nutritional issues are of major importance as populations around the world are considerably changing their diet and lifestyle with large health consequences. Food related-diseases such as obesity, diabetes, cardiovascular diseases, malnutrition and cancers are becoming major public health issues. CRNHs is the network of French research centres for human nutrition. CRNHs has the ambition to provide scientific answers to nutrition related health issues by promoting science and accelerating technology transfer to society. CRNHs aims to improve the knowledge on the functional properties of food and particularly its effects on metabolism and on human physiology by developing multi center programs using its platforms and its specific skills. CRNHs contributes to technology transfer between hospital sectors, research laboratories and industries. CRNHs’ expertise, its platforms for clinical exploration, analysis and data processing offer significant opportunities for collaborations. CRNHs develops research programs in nutrition within the framework of national, European and international research programs, working closely with industry partners and researchers worldwide. To advise on strategic development, CRNHs has been endowed with an external scientific advisory board composed of experts from several European.

- Create a research pole of experts

- Coordinate and lead multicentric research program to improve the knowledge in human nutrition

- Create a platform between laboratories and hopitals for the translational research

- Answer to public health major issues by giving a scientific answer to the nutrition problem

Director : Pr Martine Laville (CRNH Rhône Alpes)
Co-directors : Pr Noel Cano (CRNH Auvergne), Alain Grynberg (CRNH Ile de France), Pr Michel Krempf (CRNH Ouest)

In France there is now four CRNH having common tools and complementary scientific skills. Graph CRNHs

Target tissues

Nutrition in elderly and in chronic diseases



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Dicopper chloride trihydroxide


imageDicopper chloride trihydroxide

Micronutrients TBCC Intellibond C Copper Hydroxychloride

Paratacamite: rhombohedral

Clinoatacamite: monoclinic

Botallackite: monoclinic

Dicopper chloride trihydroxide is the chemical compound with the formula Cu2(OH)3Cl. It is often referred to as tribasic copper chloride (TBCC), copper trihydroxyl chloride or copper hydroxychloride. It is a greenish crystalline solid encountered in mineral deposits, metal corrosion products, industrial products, art and archeological objects, and some living systems. It was originally manufactured on an industrial scale as a precipitated material used as either a chemical intermediate or a fungicide. Since 1994, a purified, crystallized product has been produced at the scale of thousands of tons per year, and used extensively as a nutritional supplement for animals.

Cu2(OH)3Cl occurs as natural minerals in four polymorphic crystal forms: atacamite, paratacamite, clinoatacamite, and botallackite. Atacamite is orthorhombic, paratacamite is rhombohedral, and the other two polymorphs are monoclinic. Atacamite and paratacamite are common secondary minerals in areas of copper mineralization and frequently form as corrosion products of Cu-bearing metals.

The most common Cu2(OH)3Cl polymorph is atacamite. It is an oxidation product of other copper minerals, especially under arid, saline conditions. It was found in fumarolic deposits, and a weathering product of sulfides in subsea black smoker deposits. It was named for the Atacama Desert in Chile. Its color varies from blackish to emerald green. It is the sugar-like coating of dark green glistening crystals found on many bronze objects from Egypt and Mesopotamia. It has also been found in living systems such as the jaws of the marine bloodworm Glycera dibranchiate. The stability of atacamite is evidenced by its ability to endure dynamic regimes in its natural geologic environment.



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