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Glycemic load


The glycemic load (GL) of food is a number that estimates how much the food will raise a person's blood glucose level after eating it. One unit of glycemic load approximates the effect of consuming one gram of glucose. Glycemic load accounts for how much carbohydrate is in the food and how much each gram of carbohydrate in the food raises blood glucose levels. Glycemic load is based on the glycemic index (GI), and is calculated by multiplying the grams of available carbohydrate in the food times the food's GI and then dividing by 100.

Glycemic load estimates the impact of carbohydrate consumption using the glycemic index while taking into account the amount of carbohydrate that is consumed. GL is a GI-weighted measure of carbohydrate content. For instance, watermelon has a high GI, but a typical serving of watermelon does not contain much carbohydrate, so the glycemic load of eating it is low. Whereas glycemic index is defined for each type of food, glycemic load can be calculated for any size serving of a food, an entire meal, or an entire day's meals.

Glycemic load of a serving of food can be calculated as its carbohydrate content measured in grams (g), multiplied by the food's GI, and divided by 100. For example, watermelon has a GI of 72. A 100 g serving of watermelon has 5 g of available carbohydrates (it contains a lot of water), making the calculation 5 × 72/100=3.6, so the GL is 3.6. A food with a GI of 100 and 10 g of available carbohydrates has a GL of 10 (10 × 100/100=10), while a food with 100 g of carbohydrate and a GI of just 10 also has a GL of 10 (100 × 10/100=10).

For one serving of a food, a GL greater than 20 is considered high, a GL of 11–19 is considered medium, and a GL of 10 or less is considered low. Foods that have a low GL in a typical serving size almost always have a low GI. Foods with an intermediate or high GL in a typical serving size range from a very low to very high GI.

One 2007 study has questioned the value of using glycemic load as a basis for weight-loss programmes. Das et al. conducted a study on 36 healthy, overweight adults, using a randomised test to measure the efficacy of two diets, one with a high glycemic load and one with a low GL. The study concluded that there is no statistically significant difference between the outcome of the two diets.

Glycemic load appears to be a significant factor in dietary programs targeting metabolic syndrome, insulin resistance, and weight loss; studies have shown that sustained spikes in blood sugar and insulin levels may lead to increased diabetes risk. The Shanghai Women's Health Study concluded that women whose diets had the highest glycemic index were 21 percent more likely to develop type 2 diabetes than women whose diets had the lowest glycemic index. Similar findings were reported in the Black Women's Health Study. A diet program that manages the glycemic load aims to avoid sustained blood-sugar spikes and can help avoid onset of type 2 diabetes. For diabetics, glycemic load is a highly recommended tool for managing blood sugar.



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Glycemic index


The glycemic index or glycaemic index (GI) is a number associated with a particular type of food that indicates the food's effect on a person's blood glucose (also called blood sugar) level. A value of 100 represents the standard, an equivalent amount of pure glucose.

The GI represents the rise in a person's blood sugar level two hours after consumption of the food. The glycemic effect of foods depends on a number of factors, such as the type of starch, physical entrapment of the starch molecules within the food, fat and protein content of the food and organic acids or their salts in the meal. The GI is useful for understanding how the body breaks down carbohydrates and only takes into account the available carbohydrate (total carbohydrate minus fiber) in a food.

The glycemic index is usually applied in the context of the quantity of the food and the amount of carbohydrate in the food that is actually consumed. A related measure, the glycemic load (GL), factors this in by multiplying the glycemic index of the food in question by the carbohydrate content of the actual serving. Watermelon has a high glycemic index, but a low glycemic load for the quantity typically consumed.Fructose, by contrast, has a low glycemic index, but can have a high glycemic load if a large quantity is consumed.

GI tables are available that list many types of foods and their GIs. Some tables also include the serving size and the glycemic load of the food per serving.

A practical limitation of the glycemic index is that it does not measure insulin production due to rises in blood sugar. As a result, two foods could have the same glycemic index, but produce different amounts of insulin. Likewise, two foods could have the same glycemic load, but cause different insulin responses. Furthermore, both the glycemic index and glycemic load measurements are defined by the carbohydrate content of food. For example, when eating steak, which has no carbohydrate content but provides a high protein intake, up to 50% of that protein can be converted to glucose when there is little to no carbohydrate consumed with it. But because it contains no carbohydrate itself, steak cannot have a glycemic index. For some food comparisons, the "insulin index" may be more useful.

Glycemic index charts often give only one value per food, but variations are possible due to variety, ripeness (riper fruits contain more sugars increasing GI), cooking methods (the more cooked, or over cooked, a food, the more its cellular structure is broken, with a tendency for it to digest quickly and raise GI more), processing (e.g., flour has a higher GI than the whole grain from which it is ground as grinding breaks the grain's protective layers) and the length of storage. Potatoes are a notable example, ranging from moderate to very high GI even within the same variety.



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Gluten


Gluten (from Latin , "glue") is a mixture of proteins found in wheat and related grains, including barley, rye, oat (depending on cultivar and processing), and all their species and hybrids (such as spelt,kamut, and triticale). Gluten is appreciated for its viscoelastic properties. It gives elasticity to dough, helping it rise and keep its shape and often gives the final product a chewy texture.

Gluten is a composite of storage proteins termed prolamins. It is conjoined with starch in the endosperm of various grass-related grains. Wheat prolamins are called gliadins and glutenins, barley prolamins are hordeins, rye prolamins are secalins and oats prolamins are avenins.Oat avenin toxicity in people with gluten-related disorders depends on the oat cultivar consumed because the immunoreactivities of toxic prolamins are different among oat varieties. Also, many oat products are cross-contaminated with gluten-containing cereals.

The fruit of most flowering plants have endosperms with stored protein to nourish embryonic plants during germination. True gluten is limited to certain members of the grass family. The stored proteins of maize and rice are sometimes called glutens, but their proteins differ from true gluten.



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Glycogen


Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in humans, animals and fungi. The polysaccharide structure represents the main storage form of glucose in the body.

In humans, glycogen is made and stored primarily in the cells of the liver and the muscles, hydrated with three or four parts of water. Glycogen functions as the secondary long-term energy storage, with the primary energy stores being fats held in adipose tissue. Muscle glycogen is converted into glucose by muscle cells, and liver glycogen converts to glucose for use throughout the body including the central nervous system.

Glycogen is the analogue of starch, a glucose polymer that functions as energy storage in plants. It has a structure similar to amylopectin (a component of starch), but is more extensively branched and compact than starch. Both are white powders in their dry state. Glycogen is found in the form of granules in the cytosol/cytoplasm in many cell types, and plays an important role in the glucose cycle. Glycogen forms an energy reserve that can be quickly mobilized to meet a sudden need for glucose, but one that is less compact than the energy reserves of triglycerides (lipids).

In the liver, glycogen can make up from 5–6% of the organ's fresh weight (100–120 g in an adult). Only the glycogen stored in the liver can be made accessible to other organs. In the muscles, glycogen is found in a low concentration (1–2% of the muscle mass). The amount of glycogen stored in the body—especially within the muscles, liver, and red blood cells—mostly depends on physical training, basal metabolic rate, and eating habits. Small amounts of glycogen are found in the kidneys, and even smaller amounts in certain glial cells in the brain and white blood cells. The uterus also stores glycogen during pregnancy to nourish the embryo.



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GNC (store)


imageGNC Holdings Inc.

GNC Holdings Inc. is a Pittsburgh, Pennsylvania-based American commercial enterprise focused on the retail sale of health and nutrition related products, including vitamins, supplements, minerals, herbs, sports nutrition, diet, and energy products.

In 1935, David Shakarian opened a small health food store, Lackzoom, in downtown Pittsburgh. He only made USD $35 on his first day, but was able to open a second store within six months. A year later, Shakarian suffered from what appeared to be a fatal blow when the Ohio River flooded on St. Patrick's Day. Both of his stores were wiped out. However, he quickly rebuilt both stores, and opened five more by 1941. The company officially registered as a corporation on September 1, 1936 Shakarian moved into the mail order business during WWII. He said that customers sent him a check and asked him to mail their product as they could not drive to his store due to the gas rationing which happened during WWII. During the health food craze of the 1960s, Shakarian expanded his chain outside Pittsburgh for the first time, and in the process changed its name to General Nutrition Center. He continued to run the chain until his death in 1984. Shakarian took GNC public (listed on the NYSE)in the 1980s. Overexpansion and his death in 1984 resulted in a highly leveraged GNC. The Shakarian family decided to sell GNC shortly after his death. The family brought in a "turn around" executive, Jerry Horn, with instructions to "stop the bleeding" and position GNC to be sold. In 1990 the company considered relocating but a public/private effort retained GNC headquarters in Downtown Pittsburgh. GNC was taken private and sold to The Thomas Lee Company, a PE investment/management fund in the late 1980s. Thomas Lee ran GNC and took it public prior to selling the company to Royal Dutch Numico and Numico acquired GNC in 1999; it sold GNC to Apollo Management in 2003. Ontario Teachers' Pension Plan and Ares Management bought GNC in 2007. GNC went public in 2011.



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Guideline Daily Amount


Guideline Daily Amounts (GDAs) are a nutrition facts label that originally began in 1998 as a collaboration between the UK government, the food industry and consumer organizations. The process was overseen by the Institute of Grocery Distribution (IGD). To help consumers make sense of the nutrition information provided on food labels, they translate science into consumer friendly information, providing guidelines on pack that help consumers put the nutrition information they read on a food label into the context of their overall diet.

GDAs are guidelines for healthy adults and children about the approximate amount of calories, fat, saturated fat, total sugars, and sodium/salt. The GDA labels have the percentage of daily value per serving and the absolute amount per serving of these categories. The front-of-packages (FOP) GDAs must at least have calories listed, but the back-of-package (BOP) GDAs must list, at a minimum, these five.

A modified version of the GDA system was adopted by the Australian food and beverage industry in 2006 and called the 'Daily Intake Guide'. In 2009 the original GDA system was adopted as an industry standard in the European Union and in 2012 a variant was adopted in the US and called 'Facts Up Front'.

Since introduction into the world outside the UK there has been controversy on what the GDAs actually show, for example, calculating a personal R.I., which is dependent on a person's height, weight, amount of daily activity and age, an intake rating which is about 5-10% above what that person should actually be eating and drinking. When calculating the GDAs the CIAA uses the average caloric intake needed for women because this best fits the needs of the majority of the population. Women need, on average, between 1800–2200 kilocalories (kcal) a day whereas children need between 1500–2000 kcal and men 2200–2700 kcal. In March 2009, the European Food Safety Authority published its opinion on intake levels for Europe and they were consistent with numbers behind the GDAs developed in the UK.

Moreover, not all categories are equal. While a GDA for calorific intake might represent a broad target in so far as people need to take in a minimum of calories to survive, the GDA for saturated fat is not a target, as ingesting no saturated fats at all would not be harmful to health, so long as there were fats of a non-saturated variety in the diet.

GDAs are now in widespread use across the food industry and appear both on the front and back of food packaging.

In 2014, GDAs were beginning to be replaced by reference intakes.



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Health effects of chocolate


The health effects of chocolate are the possible positive and negative effects on health of eating chocolate.

Unconstrained consumption of large quantities of any energy-rich food, such as chocolate, without a corresponding increase in activity, increases the risk of obesity. Raw chocolate is high in cocoa butter, a fat removed during chocolate refining, then added back in varying proportions during manufacturing. Manufacturers may add other fats, sugars, and powdered milk as well.

Although considerable research has been conducted to evaluate the potential health benefits of consuming chocolate, there are insufficient studies to confirm any effect and no medical or regulatory authority has approved any health claim.

Overall evidence is insufficient to determine the relationship between chocolate consumption and acne. One preliminary study concluded that in males who are prone to acne, eating chocolate increases the severity of acne. Various studies point not to chocolate, but to the high glycemic nature of certain foods, like sugar, corn syrup, and other simple carbohydrates, as potential causes of acne, along with other possible dietary factors.

Food, including chocolate, is not typically viewed as addictive. Some people, however, may want or crave chocolate, leading to a self-described term, chocoholic.

It has been claimed that chocolate is an aphrodisiac, but there are no rigorous studies to prove this effect.

Reviews support a short-term effect of lowering blood pressure by consuming cocoa products, but there is no evidence of long-term cardiovascular health benefit. While daily consumption of cocoa flavanols (minimum dose of 200 mg) appears to benefit platelet and vascular function, there is no good evidence to support an effect on heart attacks or strokes.

Chocolate contains caffeine and theobromine, both mild stimulants,



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Health effects of natural phenols and polyphenols


Because of the large structural diversity and extensive metabolism of dietary polyphenols, it is difficult to determine their fate in vivo and assert specific health effects. Although many are speculated to be part of the health-promoting effects of consuming fruits and vegetables, no evidence exists to date that dietary polyphenols actually provide health benefits. To what extent effects would apply to entire organisms, and clinical outcomes in human disease in particular, remains an undefined topic in nutrition science and disease prevention.

Polyphenols have poor bioavailability, indicating that most of what are consumed are extensively metabolized and excreted.Gallic acid and isoflavones may show absorption of about 5%, with amounts of catechins (flavan-3-ols), flavanones, and quercetin glucosides even less. The least well-absorbed phenols are the proanthocyanidins, galloylated tea catechins, and anthocyanins.

A review published in 2012 found insufficient consensus for the hypothesis that the specific intake of food and drink containing flavonoids may play a meaningful role in reducing the risk of cardiovascular disease. The reviewers stated that research to date had been of poor quality and the large and rigorous trials are needed better to study the science, and to investigate possible adverse effects associated with excessive polyphenol intake. Currently, lack of knowledge about safety suggests that polyphenol levels should not exceed that which occurs in a normal diet.

As interpreted by the Linus Pauling Institute and the European Food Safety Authority (EFSA), dietary flavonoids have little or no direct antioxidant food value following digestion. Unlike controlled test tube conditions where antioxidant effects may result when high concentrations of flavonoids are used, the fate of ingested flavonoids in vivo shows they are poorly conserved (less than 5%), with most of what is absorbed existing as chemically-modified metabolites destined for rapid excretion.



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Health effects of salt


The health effects of salt are the conditions associated with the consumption of either too much or too little salt. Salt is a mineral composed primarily of sodium chloride (NaCl) and is used in food for both preservation and flavor. Sodium ions are needed in small quantities by most living things, as are chloride ions. Salt is involved in regulating the water content (fluid balance) of the body. The sodium ion itself is used for electrical signaling in the nervous system.

Salt consumption has increased during modern times. Scientists have become aware of health risks associated with high salt intake, including high blood pressure in sensitive individuals. Therefore, health authorities recommend limitations on dietary sodium. The United States Department of Health and Human Services recommends that individuals consume no more than 1500–2300 mg of sodium (3750–5750 mg of salt) per day depending on age.

As an essential nutrient, sodium is involved in numerous cellular and organ functions. Salt intake that is too low may also increase risk for cardiovascular disease and early death.

Hypernatremia, a blood sodium level above 145 mEq/L, causes thirst, and due to brain cell shrinkage may cause confusion, muscle twitching or spasms. With severe elevation, seizures and comas may occur. Death can be caused by ingestion of large amounts of salt at a time (about 1 g per kg of body weight). Deaths have also been caused by use of salt solutions as emetics (typically after suspected poisoning), forced salt intake, and accidental use of salt instead of similar-looking sugar in food.

Hyponatremia, or blood sodium levels below 135 mEq/L, causes brain cells to swell; the symptoms can be subtle and may include altered personality, lethargy, and confusion. In severe cases, when blood sodium falls below 115 mEq/L, stupor, muscle twitching or spasms, seizures, coma, and death can result. Acute hyponatremia is usually caused by drinking too much water, with insufficient salt intake.



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