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MRC Human Nutrition Research


imageMRC Human Nutrition Research

MRC Human Nutrition Research is the largest research institute in the UK for human nutrition, and is based in Cambridge.

In 1998 MRC Human Nutrition Research (HNR) was formed as a result of the restructuring of the Dunn Human Nutrition Unit following the resignation of Professor Roger Whitehead. The Medical Research Council (MRC), founded in 1913, had previously had a Human Nutrition Research Unit at the end of the Second World War; this was founded and directed by BS Platt, and was interested in serious nutritional deficiencies in children, that would cause significantly premature death. HNR was formed in order to continue to advance the MRC's portfolio of strategic and applied nutrition research.

The mission of HNR is to conduct nutrition research and surveillance to improve the health of the population with a focus on obesity and metabolic risk, musculoskeletal health, intestinal health and nutritional inequalities.

HNR currently states that its 4 objectives are to:

HNR is based at Peterhouse Technology Park, in south-east Cambridge, on the South Cambridgeshire-Cambridge boundary, round the corner from the Fulbourn - Cherry Hinton Tesco and Fulbourn Hospital. ARM Holdings have their headquarters on the same site.

It is divided into 3 main research departments and a support department:

These departments house research groups concerned with:

HNR also has a library which houses an important collection of historically significant research documents.

HNR conducts nutrition research and surveillance to improve the health of the population with a focus on obesity and metabolic risk, musculoskeletal health, intestinal health and nutritional inequalities.



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National Institute of Nutrition, Hyderabad


imageNational Institute of Nutrition

The National Institute of Nutrition (NIN) is an Indian Public health, Biotechnology and Translational research center located in Hyderabad, India. The institute is one of the oldest research centers in India, and the largest center, under the Indian Council of Medical Research, located in the vicinity of Osmania University. The institute has associated clinical and pediatric nutrition research wards at various hospitals such as the Niloufer Hospital for Women and Children, the Government Maternity Hospital, the Gandhi Medical College and the Osmania General Hospital in Hyderabad.

The National Centre for Laboratory Animal Science (to be integrated into the National Animal Resource Facility for Biomedical Research), and the Food & Drug Toxicology Research Centre, National Nutrition Monitoring Bureau are the other wings of NIN, for India's Ministry of Health and Family Welfare. The institute also derives funding from the Indian Department of Biotechnology. The institute majorly conducts research in obesity, diabetes, food chemistry, dietetics, drug toxicology, and micronutrient deficiency in collaboration with centers such as the Rockefeller University, University of Colorado School of Medicine, Washington University, and the Johns Hopkins Bloomberg School of Public Health in the U.S.. and the University of Wollongong in Australia.



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Nesfatin-1


Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Increased nesfatin-1 in the hypothalamus contributes to diminished hunger, a 'sense of fullness', and a potential loss of body fat and weight.

A study of metabolic effects of nesfatin-1 in rats have been done in which subjects administered nesfatin-1 ate less, used more stored fat and became more active. Nesfatin-1-induced inhibition of feeding may be mediated through the inhibition of orexigenic neurons. In addition, the protein stimulated insulin secretion from the pancreatic beta cells of both rats and mice.

Nesfatin-1 is a polypeptide encoded in the N-terminal region of the protein precursor, Nucleobindin2 (NUCB2). Recombinant human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues. Nesfatin-1 is expressed in the hypothalamus, in other areas of the brain, and in pancreatic islets, gastric endocrine cells and adipocytes.

Nesfatin/NUCB2 is expressed in the appetite-control hypothalamic nuclei such as paraventricular nucleus (PVN), arcuate nucleus (ARC), supraoptic nucleus (SON) of hypothalamus, lateral hypothalamic area (LHA), and zona incerta in rats. Nesfatin-1 immunoreactivity was also found in the brainstem nuclei such as nucleus of the solitary tract (NTS) and Dorsal nucleus of vagus nerve.



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Network for Capacity Development in Nutrition


The UN System Standing Committee on Nutrition (SCN), established a set of working groups (WG) on Capacity Development (CD) in close collaboration with the United Nations University (UNU). The Network had one initial meeting in 2005 and five meetings between 2006 and 2010; results are published in scientific journals and the reports are available on the Network's official website. Currently there are nine SCN WGs, of which NCDNCEE is one. NCDNCEE Capacity Development in food and nutrition is much more than formal training. It includes human resource development, organizational, institutional and legal framework development with aim of enhancing knowledge and skills. This is essential for the contribution of professionals to the improvement of the food and nutrition situation in all countries. CD is a long term, continuing process, gives primacy to national priorities, plans, policies and processes. Participants over the last years came from the following countries: Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Estonia, Macedonia, Hungary, Poland, Republika Srpska, Romania, Serbia, Slovakia, Slovenia and facilitators came from the Netherlands and Norway.

Network for Capacity Development in Nutrition and link to following EC Projects:

The general objective of the NCDN CEE Network is to initiate and support CD activities in research and training in CEE countries based on country specific needs. Specifically to the region the objectives will be linked to the specific topics of interest for the Network at any time. This is to be open for new challenges following the changes in the various countries over time.

Established in 1974 by FAO and European research institutions, the European System of Cooperative Research Networks in Agriculture (ESCORENA) became an umbrella for cooperation between research institutions focused on food, agriculture and related fields. Since its foundation, ESCORENA has expanded to include 19 networks, including UNU/SCN NCDN CEE. In 2009 with the financial support of FAO REU and technical support of the Food and Agriculture Organization of the United Nations, a new server was set up in Rome to serve as common technical background for the AgroWeb Network, ESCORENA and the Thematic Knowledge Networks operational in the framework of ESCORENA in the region.



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Nutrient enema


A nutrient enema, also known as feeding per rectum, rectal alimentation, or rectal feeding, is an enema administered with the intent of providing nutrition when normal eating is not possible. Although this treatment is ancient, dating back at least to Galen and a common technique in 19th century medicine, nutrient enemas have been superseded in modern medical care by tube feeding and intravenous feeding.

A variety of different mixes have been used for nutrient enemas throughout history. A paper published in Nature in 1926 stated that because the rectum and lower digestive tract lack digestive enzymes, it is likely that only the end-products of normal digestion such as sugars, amino acids, salt and alcohol, will be absorbed.

This treatment was given to U.S. President James A. Garfield after his shooting in 1881, and is asserted to have prolonged his life.

When the United States Senate Intelligence Committee published an unclassified summary of its 6,000 page classified report on the CIA's use of torture, its previously unknown use of "rectal rehydration" for punishment and torture became apparent.



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Nutraceutical


A Nutraceutical is a pharmaceutical-grade and standardized nutrient. Nutraceuticals are regulated by FDA under the authority of the Federal Food, Drug, and Cosmetic Act.

Nutraceuticals are treated differently in different jurisdictions.

Under Canadian law, a nutraceutical can either be marketed as a food or as a drug; the terms "nutraceutical" and "functional food" have no legal distinction, referring to "a product isolated or purified from foods that is generally sold in medicinal forms not usually associated with food [and] is demonstrated to have a physiological benefit or provide protection against chronic disease."

The term "nutraceutical" is not defined by US law. Depending on its ingredients and the claims with which it is marketed, a product is regulated as a drug, dietary supplement, food ingredient, or food.

In the global market, there are significant product quality issues. Nutraceuticals from the international market may claim to use organic or ingredients, yet the lack of regulation may compromise the safety and effectiveness of products. Companies looking to create a wide profit margin may create unregulated products overseas with low-quality or ineffective ingredients.

A market research report produced in 2012 projected that the worldwide nutraceuticals market would reach US$250 billion by 2018, defining that market as "Dietary Supplements (Vitamins, Minerals, Herbals, Non-Herbals, & Others), and Functional Foods & Beverages"

Nutraceuticals are products derived from food sources that are purported to provide extra health benefits, in addition to the basic nutritional value found in foods. Depending on the jurisdiction, products may claim to prevent chronic diseases, improve health, delay the aging process, increase life expectancy, or support the structure or function of the body.

A dietary supplement is a product that contains nutrients derived from food products that are concentrated in liquid or capsule form. In the US, the Dietary Supplement Health and Education Act (DSHEA) of 1994 defined the term: “A dietary supplement is a product taken by mouth that contains a "dietary ingredient" intended to supplement the diet. The "dietary ingredients" in these products may include: vitamins, minerals, herbs or other botanicals, amino acids, and substances such as enzymes, organ tissues, glandulars, and metabolites. Dietary supplements can also be extracts or concentrates, and may be found in many forms such as tablets, capsules, softgels, gelcaps, liquids, or powders.”



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Nutrient density


Nutrient density identifies the proportion of nutrients in foods, with terms such as nutrient rich and micronutrient dense referring to similar properties. Several different national and international standards have been developed and are in use (see Nutritional rating systems).

According to the World Health Organization, nutrient profiling classifies and/or ranks foods by their nutritional composition in order to promote human (and/or animal) health and to prevent disease. Ranking by nutrient density is one such nutrient profiling strategy. Ordering foods by nutrient density is a statistical method of comparing foods by the proportion of nutrients in foods. Some such comparisons can be the glycemic index and the Overall Nutritional Quality Index.

Nutrient-dense foods such as fruits and vegetables are the opposite of energy-dense food (also called "empty calorie" food), such as alcohol and foods high in added sugar or processed cereals. Beyond its use to distinguish different types of food from each other, nutrient density allows comparison to be made for different examples or samples of the same kind of food. Nutrient density is correlated with soil quality and mineralization levels of the soil, although the relationship is complex and incorporates other dimensions.

The Academy of Nutrition and Dietetics reported in 2013 that:

Several indicators of nutrient quality have been summarized by the Academy.

The Nutrient Rich Food Index has been developed by a research coalition involving food and nutrition practitioners. This index uses nutrient profiles that have been validated against accepted measures of a healthy diet, such as the Healthy Eating Index created by the USDA.

Nutrient density is also affected by cultivar genetics and growing conditions.



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Nutrient profiling


Nutrient profiling, also nutritional profiling, is the science of classifying or ranking foods by their nutritional composition in order to promote health and prevent disease. A common use of nutrient profiling is in the creation of nutritional rating systems to help consumers identify nutritious food.



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Nutrient sensing


Nutrient sensing is a cell's ability to recognize and respond to fuel substrates such as glucose. Each type of fuel used by the cell requires an alternate pathway of utilization and accessory molecules. In order to conserve resources a cell will only produce molecules that it needs at the time. The level and type of fuel that is available to a cell will determine the type of enzymes it needs to express from its genome for utilization. Receptors on the cell membrane's surface designed to be activated in the presence of specific fuel molecules communicate to the cell nucleus via a means of cascading interactions. In this way the cell is aware of the available nutrients and is able to produce only the molecules specific to that nutrient type.

A rapid and efficient response to disturbances in nutrient levels is crucial for the survival of organisms from bacteria to humans. Cells have therefore evolved a host of molecular pathways that can sense nutrient concentrations and quickly regulate gene expression and protein modification to respond to any changes.

Cell growth is regulated by coordination of both extracellular nutrients and intracellular metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin complex 1 serve as key molecules that sense cellular energy and nutrients levels, respectively.

Living cells use ATP as the most important direct energy source. Hydrolysis of ATP to ADP and phosphate (or AMP and pyrophosphate) provides energy for most biological processes. The ratio of ATP to ADP and AMP is a barometer of cellular energy status and is therefore tightly monitored by the cell. In eukaryotic cells, AMP-activated protein kinase (AMPK) serves as a key cellular energy sensor and a master regulator of metabolism to maintain energy homeostasis.

Nutrient is a key regulator of tissue growth. The main mediator of cellular nutrient sensing is the protein kinase TOR (target of rapamycin). TOR receives information from levels of cellular amino acids and energy, and it regulates the activity of processes involved in cell growth, such as protein synthesis and autophagy. Insulin-like signaling is the main mechanism of systemic nutrient sensing and mediates its growth-regulatory functions largely through the protein kinase pathway. Other nutrition-regulated hormonal mechanisms contribute to growth control of modulating the activity of insulin-like signaling.



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Nutrient systems


Nutrient Systems (nutrient premixes) integrate functional ingredients from vitamins, minerals, amino acids, nucleotides, and nutraceuticals. These mixes are very cost-saving and beneficial to manufacturers, researchers and developers in the food and pharmaceutical industries worldwide. This is a booming business and is part of the multi-billion dollar nutrition industry worldwide. Many everyday foods and pharmaceuticals are derived from nutrient premixes.

Nutrient premixes, or "nutrient systems" are custom-designed premixed blends containing any of a wide variety of nutrients associated with health and wellness – used in the fortification of food, drinks, and pharmaceutical products.

Premixes are complex blends of ingredients. There is a science to developing the optimum premix for food or drink applications – identifying and achieving desired specifications, selecting proper market forms, ensuring quality and consistency - all without compromising taste or texture in the end product.

This problem is modeled as a classic model in dynamic programming and is known as a blending problem or . Recently, it has taken much attention in other fields of optimization such as optimum design and supply chain - and in other industrial applications dealing with non-deterministic dynamic demand from customers.



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