• Dunn Human Nutrition Unit

    Dunn Human Nutrition Unit

    • MRC Mitochondrial Biology Unit
      Biomed campus.JPG
      The Wellcome Trust/MRC building, housing the Cambridge Institute for Medical Research and the MRC Mitochondrial Biology Unit
      Abbreviation MBU
      Formation 1927
      Type Research institute
      Legal status Government agency
      Purpose research
      Headquarters The Wellcome Trust/MRC building
      Professor Massimo Zeviani
      Parent organization
      Medical Research Council
      Website MBU

      The MRC Mitochondrial Biology Unit (formerly the MRC Dunn Human Nutrition Unit) is an institution of the Medical Research Council based at the Addenbrooke’s Hospital / Cambridge Biomedical Campus site in Cambridge, England. The unit is a University of Cambridge partner institution concerned with the study of the , as this organelle has a varied and critical role in many aspects of eukaryotic metabolism and is implicated in a large number of metabolic, degenerative, and age-related human diseases.

      The Unit was originally founded in 1927 using a donation from Sir William Dunn, who left £1 million to charity on his death in 1912. Part of this money was used to fund what was then called the Dunn Nutritional Laboratory, with its research supported by the MRC. The Unit was renamed in 2009 to the Mitochondrial Biology Unit under the directorship of Professor Sir John Walker to reflect its expertise in mitochondrial research. The current director of the Unit is Professor Massimo Zeviani.

      The Unit has three major scientific aims:

      The MBU is organised into eleven independent research groups and includes 30-40 graduate students who are members of the University of Cambridge:

      The MBU is the home of several freely-accessible scientific web-resources:

      MitoMiner - a mitochondrial proteomics database that provides information on cellular localisation, function and species & tissue specific expression

      The Integrated Mitochondrial Protein Index (IMPI) - a list of all the genes and proteins that make up the mammalian mitochondrion

      Professor Massimo Zeviani (2013 - )

      Professor Sir John Walker (1998 - 2013)

      • Professor Massimo Zeviani - Molecular basis for inherited mitochondrial disease
      • Dr Judy Hirst - Understanding the molecular mechanism of complex I and its roles in human disease
      • Professor Patrick Chinnery - Mitochondrial genomics and human diseases
      • Dr Ian Fearnley - Mitochondrial proteomics
      • Dr Edmund Kunji - Understanding transport processes in mitochondria
      • Dr Michal Minczuk - Discovering the genetic links between mitochondrial dysfunction and human disease
      • Dr Mike Murphy - Targeting therapeutic and probe molecules to mitochondria, mitochondrial radical production and redox signalling
      • Dr Julien Prudent - Interactions between mitochondria and the endoplasmic reticulum in cell physiology and disease
      • Dr Alan Robinson - Understanding mitochondria using computer modelling
      • Dr Alex Whitworth - Genetic models of neurodegenerative disease
      • Professor Sir John Walker - Understanding the molecular mechanism of how ATP is made
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    • Dunn Human Nutrition Unit