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11S globulin family


11S globulin family is a family of globulin proteins chiefly found in seeds of legumes (legumin-like), along with 7S family, often found in a protein fraction within an protein isolate. They are used as storage of important nutrients for plant growth, and therefore hardy enough to pass through the human digestive system unscathed. One common example of an 11S globulin includes glycinin derived from soy.

The term 11S refers to the sedimentation coefficient, with a range of 10.5-13 versus the vicilin-like globulins (7S family) with coefficients of 7.0-9.0

It is characterized by a hexamer (with hexagonal shape). Several residues are conserved among 11S family. Like other globulins, they are not completely digested and broken into amino acids and have the potential to bind to various proteins in the body and can exert effects independent of their amino acids constituents, even after consumption. They tend to have high emulsifying effects.




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Outline of nutrition


The following is provided as an overview of and a topical guide to nutrition:

Nutrition – study of the relationship between diet and states of health and disease. The scope of nutrition science ranges from malnutrition to optimal health.



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African Nutrition Leadership Programme


The African Nutrition Leadership Programme (ANLP) is a 10 days training course that started in 2002 to assist the development of future leaders in the field of human nutrition in Africa. The emphasis of the programme is on understanding and developing the qualities and skills of leaders, team building, communication and understanding nutrition information in a broader context. The long-term aim of the ANLP is to meet the demands for leadership in Africa to solve its nutritional challenges.

The programme is designed for individuals who have experience in various fields of nutrition. Preference will be given to candidates with a postgraduate qualification, postdoctoral fellows and candidates with comparable working experience in the broader human nutrition sciences, studying or working in Africa.

The ANLP is a leadership development and networking seminar aimed at assisting the development of future leaders in the field of human nutrition in Africa. Emphasis is placed on understanding the qualities and skills of leaders, team building, communication and nutrition information in a broader context, and to understanding the role of nutrition science in the world around us.

The course is held each year at Elgro River Lodge, Free State, South Africa.

Each year, an average of 30 candidates from all around Africa participate to the ANLP.



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Alliesthesia


Alliesthesia (αλλoς (allós) - other, and αἴσθησις (aísthēsis) - sensation, perception ; French : alliesthésie, German : Alliästhesie) describes the dependence of the perception of pleasure or disgust perceived when consuming a stimulus on the "milieu intérieur" of the organism. Therefore, a stimulus capable of ameliorating the state of the interior milieu, will be perceived as pleasant. In contrast, a stimulus disturbing the milieu interne of the organism will be perceived as unpleasant or even painful. The sensation elicited therefore depends not only on the quality or on the intensity of the stimulus, but also on internal receptors, and is subjective.

Alliesthesia is a physiologic phenomenon and should not be confounded with the pathologic symptom of allesthesia.
Another phenomenon based on sensory cues and not to be confound with alliesthesia is "sensory-specific satiety".

Each of these forms of alliesthesia exists in two opposite tendencies:

The founder of the phenomenon of alliesthesia is the French physiologist Michel Cabanac. The first scientific publication from 1968 was succeeded by over 40 publications in international journals, for example: 1970 in Nature and 1971 in Science. The term alliesthesia was first mentioned in the annex of Physiological Role of Pleasure and has been chosen in collaboration with the coauthor Stylianos Nicolaïdis. Originally, alliesthesia has been discovered by experiments in human subjects, and later been confirmed in rats (Rattus norvegicus).



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Alliin


imageAlliin

Alliin /ˈæli.ɪn/ is a sulfoxide that is a natural constituent of fresh garlic. It is a derivative of the amino acid cysteine. When fresh garlic is chopped or crushed, the enzyme alliinase converts alliin into allicin, which is responsible for the aroma of fresh garlic. Garlic has been used since antiquity as a therapeutic remedy for certain conditions now associated with oxygen toxicity, and, when this was investigated, garlic did indeed show strong antioxidant and hydroxyl radical-scavenging properties, it is presumed owing to the alliin contained within.

Alliin has been found to affect immune responses in blood.

Alliin was the first natural product found to have both carbon- and sulfur-centered stereochemistry.

The first reported synthesis, by Stoll and Seebeck in 1951, begins the alkylation of L-cysteine with allyl bromide to form deoxyalliin. Oxidation of this sulfide with hydrogen peroxide gives both diastereomers of L-alliin, differing in the orientation of the oxygen atom on the sulfur stereocenter.

A newer route, reported by Koch and Keusgen in 1998, allows stereospecific oxidation using conditions similar to the Sharpless asymmetric epoxidation. The chiral catalyst is produced from diethyl tartrate and titanium isopropoxide.



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Alpha-GPC


imageAlpha-GPC

L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and other dementias.

Alpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of acetylcholine. It is a non-prescription drug in most countries and in the United States it is classified as generally recognized as safe (GRAS).

Studies have investigated the efficacy of alpha-GPC for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance. Commonly used doses are 300 to 1,200 mg daily.

Industrially, alpha-GPC is produced by the chemical or enzymatic deacylation of phosphatidylcholine enriched soya phospholipids followed by chromatographic purification. Alpha-GPC may also be derived in small amounts from highly purified soy lecithin.

Many users report degradation of alpha-GPC when stored openly or for long periods of time. Alpha-GPC is hygroscopic and will pull moisture in from the surrounding air. This will cause the powder to turn into what appears to be a gel. Alpha-GPC with >99% purity will undergo this process at a visible rate (seconds to minutes) and thus requires minimized exposure to the air. This hygroscopic quality can cause gel capsules not fully packed with alpha-GPC to dissolve. Proper storage methods need to be used with alpha-GPC and include removing all air from the container, double bagging with plastic bags rated for chemicals (less likely to leak air), and storing bulk/excess inside the freezer. Vacuum sealed bags are highly recommended. For people accessing alpha-GPC daily it is advisable to separate a month's supply from excess and storing the excess as best as possible. Vacuum sealing a large supply into many 1 month dividends is a method positively reported by many users. It is important to note that hygroscopy is not degradation and leaves the substance still usable, however, the ability to accurately weigh a dose is no longer possible as the substance being weighed will be a mixture of powder and water. Liquefied or gelled alpha-GPC may also be indicative of poor storage and thus have an increased likelihood of actual degradation.



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American Society for Parenteral and Enteral Nutrition


The American Society for Parenteral and Enteral Nutrition (ASPEN) is a US-based professional organization. Its members include dieticians, nurses, pharmacists, physicians and scientists who are involved in providing clinical nutrition to patients.

ASPEN was founded in 1976. It has over 6,000 members. Its stated mission is, "to improve patient care by advancing the science and practice of clinical nutrition and metabolism."

The society runs an annual conference, "Clinical Nutrition Week".



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Amino acid score


Amino acid score, in combination with protein digestibility, is the method used to determine if a protein is complete. PDCAAS and DIAAS are the two major protein standards which determine the completeness of proteins by their unique composition of essential amino acids.



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An apple a day keeps the doctor away


"An apple a day keeps the doctor away" is an English-language proverb claiming that apple consumption or fruits and vegetables in general has health benefits.

The first recorded use of the proverb was in the 1860s in Wales, (country of United Kingdom). The original wording of the saying was "Eat an apple on going to bed, and you’ll keep the doctor from earning his bread." The current phrasing ("An apple a day keeps the doctor away") was first used in print in 1922.

A 2011 study found that consumption of apples and pears might prevent strokes. A 2012 study found that apple consumption significantly lowered bad cholesterol levels in middle-aged adults. In 2013, the BMJ published a study as part of its humorous Christmas issue comparing the effects of prescribing everyone in the UK over age 50 either an apple or a statin a day. The study concluded that both interventions would be similarly effective.

A 2015 study looked directly at the relationship between apple consumption and physician visits and found no evidence that the proverb was true. The study did, however, find that people who ate an apple a day did use fewer prescription medications.

However, a 2011 study found that adding one ‘Golden Delicious’ apple to the daily diet of a small group of overweight men led to higher levels of LDL cholesterol and triglycerides. The higher sugar and low-phenolic content of ‘Golden Delicious’ apples was blamed for the results.



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Animal nutrition


Animal nutrition focuses on the dietary needs of domesticated animals, primarily those in agriculture and food production.

There are seven major classes of nutrients: carbohydrates, fats, fibre, minerals, protein, vitamin, and water.

The macronutrients (excluding fiber and water) provide structural material (amino acids from which proteins are built, and lipids from which cell membranes and some signaling molecules are built) and energy. Some of the structural material can be used to generate energy internally, and in either case it is measured in joules or calories (sometimes called "kilocalories" and on other rare occasions written with a capital C to distinguish them from little 'c' calories). Carbohydrates and proteins provide 17 kJ approximately (4 kcal) of energy per gram, while fats provide 37 kJ (9 kcal) per gram., though the net energy from either depends on such factors as absorption and digestive effort, which vary substantially from instance to instance. Vitamins, minerals, fiber, and water do not provide energy, but are required for other reasons. A third class dietary material, fiber (i.e., non-digestible material such as cellulose), seems also to be required, for both mechanical and biochemical reasons, though the exact reasons remain unclear.

Molecules of carbohydrates and fats consist of carbon, hydrogen, and oxygen atoms. Carbohydrates range from simple monosaccharides (glucose, fructose, galactose) to complex polysaccharides (starch). Fats are triglycerides, made of assorted fatty acid monomers bound to glycerol backbone. Some fatty acids, but not all, are essential in the diet: they cannot be synthesized in the body. Protein molecules contain nitrogen atoms in addition to carbon, oxygen, and hydrogen. The fundamental components of protein are nitrogen-containing amino acids, some of which are essential in the sense that humans cannot make them internally. Some of the amino acids are convertible (with the expenditure of energy) to glucose and can be used for energy production just as ordinary glucose. By breaking down existing protein, some glucose can be produced internally; the remaining amino acids are discarded, primarily as urea in urine. This occurs normally only during prolonged starvation.



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