Recombinant bovine somatotropin

Bovine somatotropin or bovine somatotrophin (abbreviated bST and BST), or bovine growth hormone (BGH), is a peptide hormone produced by cows' pituitary glands. Like other hormones, it is produced in small quantities and is used in regulating metabolic processes. After the biotech company Genentech discovered and patented the gene for BST in the 1970s, it became possible to synthesize the hormone using recombinant DNA technology to create recombinant bovine somatotropin (rBST), recombinant bovine growth hormone (rBGH), or artificial growth hormone. Four large pharmaceutical companies, Monsanto, American Cyanamid, Eli Lilly, and Upjohn, developed commercial rBST products and submitted them to the US Food and Drug Administration (FDA) for approval. Monsanto was the first firm to receive approval. Other countries (Mexico, Brazil, India, Russia, and at least ten others) also approved rBST for commercial use. Monsanto licensed Genentech's patent, and marketed their product as "Posilac". In October 2008, Monsanto sold this business, in full, to Eli Lilly and Company for $300 million plus additional consideration.

rBST has not been allowed on the market in Canada, Australia, New Zealand, Japan, Israel, or the European Union since 2000. Argentina also banned the use of rBST.

The FDA,World Health Organization, and National Institutes of Health have independently stated that dairy products and meat from BST-treated cows are safe for human consumption. In the United States, public opinion led some manufacturers and retailers to market only milk that is rBST-free.

A European Union report on the animal welfare effects of rBST states that its use often results in "severe and unnecessary pain, suffering and distress" for cows, "associated with serious mastitis, foot disorders and some reproductive problems".

...
Wikipedia