U.S. Route 64 in North Carolina

U.S. Route 64
Route of US 64 in North Carolina highlighted in red
Route information
Maintained by NCDOT
Length:	604 mi (972 km)
Existed:	1932 – present
Tourist routes:	Mountain Waters Scenic Byway Waterfall Byway Black Mountain Rag Alligator River Route Roanoke Voyages Corridor
Major junctions
West end:	US 64 / US 74 / SR 40 at the Tennessee line
	US 23 / US 441 in Franklin I‑26 / US 25 / US 74 in Hendersonville US 321 / NC 90 in Lenoir US 52 in Lexington I‑85 near Lexington I‑73 / I‑74 / US 220 in Asheboro US 421 in Siler City I‑40 / I‑440 / US 1 in Raleigh I‑495 / I‑540 in Knightdale I‑95 in Rocky Mount US 13 / US 17 in Williamston
East end:	US 158 / NC 12 at Whalebone Junction
Location
Counties:	Cherokee, Clay, Macon, Jackson, Transylvania, Henderson, Rutherford, McDowell, Burke, Caldwell, Alexander, Iredell, Davie, Davidson, Randolph, Chatham, Wake, Franklin, Nash, Edgecombe, Martin, Washington, Tyrell, Dare
Highway system
United States Numbered Highway System List Special Divided Replaced North Carolina Highway System Interstate U.S. State Scenic ← NC 63 NC 65 →

U.S. Route 64 (US 64) is the longest numbered route in the U.S. state of North Carolina, running 604 miles (972 km) from the Tennessee state line to the Outer Banks. The route passes through the westernmost municipality in the state, Murphy, and one of the most easternmost municipalities, Manteo, making US 64 a symbolic representation of the phrase "from Murphy to Manteo" which is used to refer to the expanse of the state. The highway is a major east-west route through the central and eastern portion of the state.

US 64 enters North Carolina in Cherokee County, west of Murphy. The highway serves the cities of Hendersonville, Brevard, Rutherfordton, Morganton, Lenoir, Statesville, Lexington, Asheboro, Siler City, Raleigh, Rocky Mount, Tarboro, Williamston, and Manteo.