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TPST2

Tyrosylprotein Sulfotransferase
TPST OneSubunit WhiteBG.png
An image of a single subunit of the catalytic region of TPST-2 from protein structure 3AP1
Identifiers
EC number 2.8.2.20
CAS number 87588-33-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
tyrosylprotein sulfotransferase 1
Identifiers
Symbol TPST1
Entrez 8460
HUGO 12020
OMIM 603125
RefSeq NM_003596
UniProt O60507
Other data
EC number 2.8.2.20
Locus Chr. 7 q11.21
tyrosylprotein sulfotransferase 2
Identifiers
Symbol TPST2
Entrez 8459
HUGO 12021
OMIM 603126
RefSeq NM_003595
UniProt O60704
Other data
EC number 2.8.2.20
Locus Chr. 22 q12.1

Tyrosylprotein sulfotransferase is an enzyme that catalyzes tyrosine sulfation.

Tyrosylprotein Sulfotransferase is the enzyme that catalyzes the sulfation reaction of protein tyrosines, a post-translational modification of proteins. It utilizes 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) as the sulfonate donor and binds proteins with target tyrosine residues to eventually form the tyrosine O-sulfate ester group and the desulfonated 3’-phosphoadenosine-5’-phosphate (PAP).

TPST and tyrosine sulfation is involved in a large number of biological and physiological processes. Tyrosine sulfation has been found to be an important part of the inflammatory process, leukocyte movement and cytosis, viral cell entrance, and other cell-cell and protein-protein interactions. Selection for specific tyrosine residues requires a generally accessible tyrosine residue, and acidic residues within +5 or -5 residues of the target tyrosine.P-selectin glycoprotein ligand-1 (PSGL-1) has been extensively studied as a substrate for TPST and the importance of sulfation in PSGL-1 and its ability to bind its receptor. Another substrate for TPST, CC-chemokine Receptor 5 (CCR5), has generated interest because of its role as the target protein for the viral entrance of HIV into cells. The importance of CCR5’s sulfation for HIV invasion has led to research on TPST and CCR5, including a characterization of the pattern of sulfation of CCR5. Beyond these two proteins, other notable protein substrates include Cholecystokinin (CCK), Factor V and Factor VIII, gastrin, the leech enzyme hirudin, fibrinogen, Complement component 4, follicle-stimulating hormone receptor (FSHR), and other chemokine and G-protein coupled receptors. A full, up-to-date list can be found at UniProtKB.


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Wikipedia

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