Factor V

F5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S9C, 1CZS, 1CZV, 3P6Z, 3P70
Identifiers
Aliases	F5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
External IDs	OMIM: 612309 MGI: 88382 HomoloGene: 104 GeneCards: F5
Gene ontology Molecular function • metal ion binding • protein binding • copper ion binding • serine-type endopeptidase activity Cellular component • platelet alpha granule • extracellular vesicle • endoplasmic reticulum lumen • membrane • plasma membrane • extracellular region • ER to Golgi transport vesicle • endoplasmic reticulum-Golgi intermediate compartment membrane • platelet alpha granule lumen • Golgi apparatus • endoplasmic reticulum • Golgi membrane • extracellular space Biological process • hemostasis • platelet degranulation • blood coagulation • blood circulation • ER to Golgi vesicle-mediated transport • COPII vesicle coating • platelet activation • proteolysis • response to vitamin K Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2153	14067
Ensembl	ENSG00000198734	ENSMUSG00000026579
UniProt	P12259	O88783
RefSeq (mRNA)	NM_000130	NM_007976
RefSeq (protein)	NP_000121	NP_032002.1 NP_032002
Location (UCSC)	Chr 1: 169.51 – 169.59 Mb	Chr 1: 164.15 – 164.22 Mb
PubMed search

3S9C, 1CZS, 1CZV, 3P6Z, 3P70

2153

14067

ENSG00000198734

ENSMUSG00000026579

P12259

O88783

NM_000130

NM_007976

NP_000121

NP_032002.1
NP_032002

Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.

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Wikipedia