P-selectin glycoprotein ligand-1

SELPLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G1S
Identifiers
Aliases	SELPLG, CD162, CLA, PSGL-1, PSGL1, selectin P ligand
External IDs	MGI: 106689 HomoloGene: 2261 GeneCards: SELPLG
Genetically Related Diseases
conduct disorder
Gene ontology Molecular function • receptor binding • protein binding • virus receptor activity Cellular component • uropod • integral component of plasma membrane • integral component of membrane • membrane • plasma membrane Biological process • leukocyte migration • cellular response to interleukin-6 • leukocyte adhesive activation • viral entry into host cell • viral process • cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6404	20345
Ensembl	ENSG00000110876	ENSMUSG00000048163
UniProt	Q14242	Q62170
RefSeq (mRNA)	NM_001206609 NM_003006	NM_009151
RefSeq (protein)	NP_001193538 NP_002997	n/a
Location (UCSC)	Chr 12: 108.62 – 108.63 Mb	Chr 5: 113.82 – 113.83 Mb
PubMed search

1G1S

6404

20345

ENSG00000110876

ENSMUSG00000048163

Q14242

Q62170

NM_001206609
NM_003006

NM_009151

NP_001193538
NP_002997

n/a

Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene.

SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin.

The organization of the SELPLG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.

P-selectin glycoprotein ligand-1 (PSGL-1) is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin.

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Wikipedia