E-selectin

SELE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ESL, 1G1T, 4C16, 4CSY
Identifiers
Aliases	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E
External IDs	MGI: 98278 HomoloGene: 389 GeneCards: SELE
Gene ontology Molecular function • phospholipase binding • oligosaccharide binding • protein binding • transmembrane signaling receptor activity • carbohydrate binding • sialic acid binding Cellular component • integral component of membrane • membrane • cortical cytoskeleton • plasma membrane • perinuclear region of cytoplasm • caveola • membrane raft • clathrin-coated pit • extracellular space Biological process • leukocyte cell-cell adhesion • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • response to interleukin-1 • positive regulation of receptor internalization • actin filament-based process • leukocyte migration involved in inflammatory response • activation of phospholipase C activity • response to tumor necrosis factor • response to lipopolysaccharide • cell adhesion • regulation of inflammatory response • leukocyte tethering or rolling • inflammatory response • leukocyte migration • calcium-mediated signaling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6401	20339
Ensembl	ENSG00000007908	ENSMUSG00000026582
UniProt	P16581	Q00690
RefSeq (mRNA)	NM_000450	NM_011345
RefSeq (protein)	NP_000441	NP_035475.1 NP_035475
Location (UCSC)	Chr 1: 169.72 – 169.76 Mb	Chr 1: 164.05 – 164.06 Mb
PubMed search

1ESL, 1G1T, 4C16, 4CSY

6401

20339

ENSG00000007908

ENSMUSG00000026582

P16581

Q00690

NM_000450

NM_011345

NP_000441

NP_035475.1
NP_035475

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene.

...
Wikipedia