CD43

SPN

Identifiers

SPN, CD43, GALGP, GPL115, LSN, sialophorin

External IDs

OMIM: 182160 MGI: 98384 HomoloGene: 36108 GeneCards: SPN

Gene ontology
Molecular function	• transmembrane signaling receptor activity
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • basement membrane • cell surface • uropod • extracellular exosome • external side of plasma membrane • extracellular space
Biological process	• negative regulation of cell adhesion • positive regulation of protein phosphorylation • negative regulation of type IV hypersensitivity • positive regulation of tumor necrosis factor biosynthetic process • response to protozoan • T cell costimulation • negative thymic T cell selection • chemotaxis • establishment or maintenance of cell polarity • cellular defense response • cell surface receptor signaling pathway • negative regulation of T cell proliferation • defense response to bacterium • immune response • positive regulation of T cell proliferation • regulation of immune response • apoptotic signaling pathway • regulation of defense response to virus • negative regulation of T cell activation • leukocyte migration • signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6693


20737

Ensembl


ENSG00000197471


ENSMUSG00000051457

UniProt


P16150


P15702

RefSeq (mRNA)


NM_001030288 NM_003123


NM_001037810 NM_009259

RefSeq (protein)


NP_001025459 NP_003114


NP_001032899.1 NP_033285.1 NP_001032899 NP_033285

Location (UCSC)

Chr 16: 29.66 – 29.67 Mb

Chr 7: 127.13 – 127.14 Mb

PubMed search

NM_001030288
NM_003123

NM_001037810
NM_009259

NP_001025459
NP_003114

NP_001032899.1
NP_033285.1
NP_001032899
NP_033285

Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.

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Wikipedia