P-selectin

SELP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FSB, 1G1Q, 1G1R, 1G1S, 1HES
Identifiers
Aliases	SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL, selectin P
External IDs	OMIM: 173610 MGI: 98280 HomoloGene: 2260 GeneCards: SELP
Gene ontology Molecular function • heparin binding • oligosaccharide binding • lipopolysaccharide binding • glycoprotein binding • calcium-dependent protein binding • protein binding • glycosphingolipid binding • fucose binding • carbohydrate binding • sialic acid binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • platelet alpha granule membrane • platelet dense granule membrane • external side of plasma membrane • extracellular space Biological process • leukocyte cell-cell adhesion • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • positive regulation of leukocyte migration • platelet degranulation • regulation of integrin activation • cell adhesion • defense response to Gram-negative bacterium • leukocyte tethering or rolling • positive regulation of phosphatidylinositol 3-kinase signaling • inflammatory response • calcium-mediated signaling using intracellular calcium source • positive regulation of platelet activation • leukocyte migration • response to lipopolysaccharide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6403	20344
Ensembl	ENSG00000174175	ENSMUSG00000026580
UniProt	P16109	Q01102
RefSeq (mRNA)	NM_003005	NM_011347
RefSeq (protein)	NP_002996 NP_002996.2	NP_035477.1 NP_035477
Location (UCSC)	Chr 1: 169.59 – 169.63 Mb	Chr 1: 164.12 – 164.15 Mb
PubMed search

1FSB, 1G1Q, 1G1R, 1G1S, 1HES

6403

20344

ENSG00000174175

ENSMUSG00000026580

P16109

Q01102

NM_003005

NM_011347

NP_002996
NP_002996.2

NP_035477.1
NP_035477

P-selectin is a protein that in humans is encoded by the SELP gene.

P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules.

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Wikipedia